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Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes  期刊论文  

  • 编号：
    7ce7e09c-37be-4534-b4ce-29ba10ac22b3
  • 作者：
    Xue, Ruidong[1,2];Chen, Lu[3];Zhang, Chong[1,2];Fujita, Masashi[4];Li, Ruoyan[1,2];Yan, ShuMei[5];Ong, Choon Kiat[6];Liao, Xiwen[7];Gao, Qiang(高强)[8,9]Sasagawa, Shota[4];Li, Yanmeng[1,2];Wang, Jincheng[1,2];Guo, Hua[10];Huang, QiTao[5];Zhong, Qian[5];Tan, Jing[5];Qi, Lisha[11];Gong, Wenchen[11];Hong, Zhixian[12];Li, Meng[13];Zhao, Jingmin[14];Peng, Tao[7];Lu, Yinying[15];Lim, Kiat Hon Tony[16];Boot, Arnoud[17];Ono, Atushi[18];Chayama, Kazuaki[18];Zhang, Zemin[1,2];Rozen, Steve George[17];Teh, Bin Tean[19];Wang, Xin Wei[20];Nakagawa, Hidewaki[4];Zeng, MuSheng[5];Bai, Fan[1,2];Zhang, Ning[1,2,10];
  • 语种：
    英文
  • 期刊：
    CANCER CELL ISSN：1535-6108 2019 年 35 卷 6 期 (932 - +) ; JUN 10
  • 收录：
     
  • 摘要：

    We performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that combined and mixed type cHCC-ICCs are distinct subtypes with different clinical and molecular features. Integrating laser microdissection, cancer cell fraction analysis, and single nucleus sequencing, we revealed both mono- and multiclonal origins in the separate type cHCC-ICCs, whereas combined and mixed type cHCC-ICCs were all monoclonal origin. Notably, cHCC-ICCs showed significantly higher expression of Nestin, suggesting Nestin may serve as a biomarker for diagnosing cHCC-ICC. Our results provide important biological and clinical insights into cHCC-ICC.

  • 推荐引用方式
    GB/T 7714：
    Xue Ruidong,Chen Lu,Zhang Chong, et al. Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes [J].CANCER CELL,2019,35(6):932-+.
  • APA：
    Xue Ruidong,Chen Lu,Zhang Chong,Fujita Masashi,&Zhang Ning.(2019).Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes .CANCER CELL,35(6):932-+.
  • MLA：
    Xue Ruidong, et al. "Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes" .CANCER CELL 35,6(2019):932-+.
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