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BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency 期刊论文

编号：

7da49e89-9af4-4c54-8d7d-42d47954e07d
作者：

Lu, Panpan^[1];Shen, Yinzhong(沈银忠)^[2,3]Yang, He^[1];Wang, Yanan^[1];Jiang, Zhengtao^[1];Yang, Xinyi^[1];Zhong, Yangcheng^[1];Pan, Hanyu^[1];Xu, Jianqing(徐建青)^[2,3]Lu, Hongzhou(卢洪洲)^[2,3]Zhu, Huanzhang^[1];
语种：

English
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2017 年 7 卷 ; NOV 30
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摘要：

Persistent latent reservoir in resting CD4+T cells is a major obstacle in curing HIV-1 infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We report here for the first time that two BET inhibitors, RVX-208, which has entered phase II clinical trials for diverse cardiovascular disorders, and PFI-1, which has been widely studied in oncology, can reactivate HIV-1 from latency. RVX-208 and PFI-1 treatment alone or in combination with other latency reversing agents efficiently reactivated HIV-1 transcription through an up-regulation of P-TEFb by increasing CDK9 Thr-186 phosphorylation in latently infected Jurkat T cells in vitro. The two BET inhibitors also reactivated HIV-1 transcription in cART treated patient-derived resting CD4+T cells ex vivo, without influence on global immune cell activation. Our findings, in combination with previous reports, further confirm that BET inhibitors are a group of leading compounds for combating HIV-1 latency for viral eradication.
推荐引用方式
GB/T 7714：

Lu Panpan,Shen Yinzhong,Yang He, et al. BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency [J].SCIENTIFIC REPORTS,2017,7.
APA：

Lu Panpan,Shen Yinzhong,Yang He,Wang Yanan,&Zhu Huanzhang.(2017).BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency .SCIENTIFIC REPORTS,7.
MLA：

Lu Panpan, et al. "BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency" .SCIENTIFIC REPORTS 7(2017).

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