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Breast-specific gamma imaging with Tc-99m-sestamibi in the diagnosis of breast cancer and its semiquantitative index correlation with tumor biologic markers, subtypes, and clinicopathologic characteristics 期刊论文

编号：

7e7e5037-0254-45c1-9e94-457eedd4f1e6
作者：

Tan, Hui(谭辉)#^[1,4,5]Zhang, Hongwei^[2];Yang, Weige^[2];Fu, Yipeng^[2];Gu, Yusen^[1,4,5];Du, Min(杜敏)^[3]Cheng, Dengfeng(程登峰)^[1,4,5]Shi, Hongcheng(石洪成)*^[1,4,5]
语种：

English
期刊：

NUCLEAR MEDICINE COMMUNICATIONS ISSN：0143-3636 2016 年 37 卷 8 期 (792 - 799) ; AUG
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关键词：

biologic markers breast cancer breast-specific gamma imaging clinicopathologic factors sensitivity Tc-99m-sestamibi
摘要：

ObjectivesTo determine the sensitivity of breast-specific gamma imaging (BSGI) in diagnosing breast cancer and assess the potential correlation between the semiquantitative index of BSGI and biologic markers, molecular subtypes, and clinicopathologic characteristics of breast cancer.Materials and methodsThe sensitivity of BSGI for breast cancer was retrospectively assessed in 102 female breast cancer patients who underwent BSGI before surgery and was compared with that of ultrasonography and mammography. BSGI was visually graded on the basis of the Society of Nuclear Medicine and Molecular Imaging guideline. Tracer uptake in the cancer as the lesion to nonlesion ratio (L/N) was calculated semiquantitatively and was subsequently correlated to tumor biologic markers, molecular subtypes, and clinicopathologic characteristics.ResultsThe sensitivity of BSGI for breast cancer by visual analysis was 94.1% (96/102) in our cohort, which was 100% (47/47) in the subgroup of patients with a tumor size more than 2.0cm and 89.1% (49/55) in the subgroup of patients with a size less than or equal to 2.0cm. The sensitivity of BSGI was significantly higher than that of ultrasonography of 84.2% (85/101) (P=0.022) and mammography of 84.5% (60/71) (P=0.037). There was no significant correlation between the L/N and expressions of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and antigen Ki-67, and the subtypes or histologic grade of the cancer (P>0.05). However, the value of L/N was associated with infiltration degree (P=0.005), axillary lymph node status (P=0.029), and tumor size (P=0.002). Multivariate analysis further indicated that the value of L/N was correlated with infiltration degree (P=0.016) and tumor size (P=0.002).ConclusionBSGI has a high sensitivity for detecting primary breast cancer. The value of L/N on BSGI was independently related to infiltration degree and tumor size of breast cancer, but not to expression of tumor receptor markers and histologic grade.
推荐引用方式
GB/T 7714：

Tan Hui,Zhang Hongwei,Yang Weige, et al. Breast-specific gamma imaging with Tc-99m-sestamibi in the diagnosis of breast cancer and its semiquantitative index correlation with tumor biologic markers, subtypes, and clinicopathologic characteristics [J].NUCLEAR MEDICINE COMMUNICATIONS,2016,37(8):792-799.
APA：

Tan Hui,Zhang Hongwei,Yang Weige,Fu Yipeng,&Shi Hongcheng.(2016).Breast-specific gamma imaging with Tc-99m-sestamibi in the diagnosis of breast cancer and its semiquantitative index correlation with tumor biologic markers, subtypes, and clinicopathologic characteristics .NUCLEAR MEDICINE COMMUNICATIONS,37(8):792-799.
MLA：

Tan Hui, et al. "Breast-specific gamma imaging with Tc-99m-sestamibi in the diagnosis of breast cancer and its semiquantitative index correlation with tumor biologic markers, subtypes, and clinicopathologic characteristics" .NUCLEAR MEDICINE COMMUNICATIONS 37,8(2016):792-799.

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