首页 / 院系成果 / 成果详情页

Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo 期刊论文

编号：

7ef8dc83-c16e-4187-993c-b0b37e7d6f34
作者：

Wang, Feng^[2] Chen, Lin^[1] Mao, ZhenBiao^[2] Shao, JianGuo^[1] Tan, Chang^[3] Huang, WeiDa^[3]
语种：

English
期刊：

ONCOLOGY REPORTS ISSN：1021-335X 2008 年 20 卷 1 期 (135 - 139) ; JUL
收录：
关键词：

a proliferation-inducing ligand gene short hairpin RNA RNA interference lentivirus pancreatic cancer
摘要：

RNA interference (RNAi) is an evolutionarily conserved process of gene silencing in multiple organisms, which has become a powerful tool for investigating gene function by reverse genetics. Herein, we constructed a short hairpin RNA (shRNA) lentiviral expression vector targeting a proliferation-inducing ligand (APRIL) gene in the CFPAC-1 cell (a type of cell strain of human pancreatic cancer) in order to observe the inhibitory effect of APRIL gene's shRNA on the growth of the CFPAC-1 cell in vitro and in vivo. The results showed that lentivirus-mediated RNAi effectively inhibited the expression of APRIL mRNA and protein in CFPAC-1 cells. Moreover, it can inhibit the growth of pancreatic cancer cells in vitro and in vivo. Our study indicates that lentivirus-mediated gene therapy is an attractive strategy in the treatment of pancreatic cancer and justifies the use of lentivirus in cancer gene therapy studies.
推荐引用方式
GB/T 7714：

Wang Feng,Chen Lin,Mao Zhen-Biao, et al. Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo [J].ONCOLOGY REPORTS,2008,20(1):135-139.
APA：

Wang Feng,Chen Lin,Mao Zhen-Biao,Shao Jian-Guo,&Huang Wei-Da.(2008).Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo .ONCOLOGY REPORTS,20(1):135-139.
MLA：

Wang Feng, et al. "Lentivirus-mediated short hairpin RNA targeting the APRIL gene suppresses the growth of pancreatic cancer cells in vitro and in vivo" .ONCOLOGY REPORTS 20,1(2008):135-139.

浏览次数：1  下载次数：0

分享到：

浏览次数：1

下载次数：0

打印次数：0