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The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo 期刊论文

编号：

810539d3-72e0-4e90-8911-36949a3891b8
作者：

Ren, Peijun^[1,2,3,4];Zou, Gang^[1];Bailly, Benjamin^[1,5];Xu, Shanshan^[1];Zeng, Mei(曾玫)^[6]Chen, Xinsheng^[7];Shen, Liang^[7];Zhang, Ying^[8];Guillon, Patrice^[5];ArenzanaSeisdedos, Fernando^[3,4];Buchy, Philippe^[9];Li, Jian^[7];von Itzstein, Mark^[5];Li, Qihan^[8];Altmeyer, Ralf^[1];
语种：

English
期刊：

EMERGING MICROBES & INFECTIONS ISSN：2222-1751 2014 年 3 卷 ; SEP 3
收录：
关键词：

anti-viral drug discovery enterovirus 71 hand, foot and mouth disease suramin
摘要：

Enterovirus 71 (EV71) causes severe central nervous system infections, leading to cardiopulmonary complications and death in young children. There is an urgent unmet medical need for new pharmaceutical agents to control EV71 infections. Using a multidisciplinary approach, we found that the approved pediatric antiparasitic drug suramin blocked EV71 infectivity by a novel mechanism of action that involves binding of the naphtalentrisulonic acid group of suramin to the viral capsid. Moreover, we demonstrate that when suramin is used in vivo at doses equivalent to or lower than the highest dose already used in humans, it significantly decreased mortality in mice challenged with a lethal dose of EV71 and peak viral load in adult rhesus monkeys. Thus, suramin inhibits EV71 infection by neutralizing virus particles prior to cell attachment. Consequently, these findings identify suramin as a clinical candidate for further development as a therapeutic or prophylactic treatment for severe EV71 infection.
推荐引用方式
GB/T 7714：

Ren Peijun,Zou Gang,Bailly Benjamin, et al. The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo [J].EMERGING MICROBES & INFECTIONS,2014,3.
APA：

Ren Peijun,Zou Gang,Bailly Benjamin,Xu Shanshan,&Altmeyer Ralf.(2014).The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo .EMERGING MICROBES & INFECTIONS,3.
MLA：

Ren Peijun, et al. "The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo" .EMERGING MICROBES & INFECTIONS 3(2014).

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