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Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses 期刊论文

编号：

81f2c499-bcb8-488d-94a6-363d534066fd
作者：

Jiang, Yuhang^[1,2];Li, Cuifeng^[1,2];Wu, Qian^[3,4,5];An, Peng^[3,4,5];Huang, Laiquan^[6];Wang, Jia^[3,4,5];Chen, Chen^[7];Chen, Xi^[1,2];Zhang, Fan^[3,4,5];Ma, Li^[8];Liu, Sanhong^[2];He, Hanqing^[9];Xie, Shuyun^[9];Sun, Yangbai^[9];Liu, Hanshao^[1,2];Zhan, Yu^[2];Tao, Yu^[2];Liu, Zhi^[1,2];Sun, Xiaohua^[1,2];Hu, Yiming^[1,2];Wang, Qi^[2];Ye, Deji^[2];Zhang, Jie^[2];Zou, Shanhua(邹善华)^[7]Wang, Ying^[2];Wei, Gang^[8];Liu, Yongzhong^[10];Shi, Yufang^[2];Chin, Y. Eugene^[2];Hao, Yongqiang^[11];Wang, Fudi^[3,4,5];Zhang, Xiaoren^[1,2];
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2019 年 10 卷 ; JUL 3
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摘要：

Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the measles vaccine when compared to iron-normal controls. Mice with iron deficiency also exhibit attenuated T-dependent or T-independent antigen-specific antibody responses. We show that iron is essential for B cell proliferation; both iron deficiency and a-ketoglutarate inhibition could suppress cyclin E1 induction and S phase entry of B cells upon activation. Finally, we demonstrate that three demethylases, KDM2B, KDM3B and KDM4C, are responsible for histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter, cyclin E1 induction and B cell proliferation. Thus, our data reveal a crucial role of H3K9 demethylation in B cell proliferation, and the importance of iron in humoral immunity.
推荐引用方式
GB/T 7714：

Jiang Yuhang,Li Cuifeng,Wu Qian, et al. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses [J].NATURE COMMUNICATIONS,2019,10.
APA：

Jiang Yuhang,Li Cuifeng,Wu Qian,An Peng,&Zhang Xiaoren.(2019).Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses .NATURE COMMUNICATIONS,10.
MLA：

Jiang Yuhang, et al. "Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses" .NATURE COMMUNICATIONS 10(2019).
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