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Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types 期刊论文

编号：

83a2e3f8-a9c4-4a7b-bed6-28059ecdad92
作者：

Song, Dongli^[1];Cretoiu, Dragos^[2,3];Zheng, Minghuan^[1];Qian, Mengjia^[1];Zhang, Miaomiao^[1];Cretoiu, Sanda M.^[2,3];Chen, Luonan^[4];Fang, Hao(方浩)^[5,6]Popescu, Laurentiu M.^[2,3];Wang, Xiangdong^[1];
语种：

English
期刊：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ISSN：1582-4934 2016 年 20 卷 1 期 (71 - 80) ; JAN
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关键词：

chromosome 4 telocytes mesenchymal stem cells fibroblasts alveolar type II cells airway epithelial cells lymphocytes
摘要：

Telocytes (TCs) are new cellular entities of mesenchymal origin described almost ubiquitously in human and mammalian organs (www.telocytes.com). Different subtypes of TCs were described, all forming networks in the interstitial space by homo-and heterocellular junctions. Previous studies analysed the gene expression profiles of chromosomes 1, 2, 3, 17 and 18 of murine pulmonary TCs. In this study, we analysed by bioinformatics tools the gene expression profiles of chromosome 4 for murine pulmonary TCs and compared it with mesenchymal stem cells (MSCs), fibroblasts (Fbs), alveolar type II cells (ATII), airway basal cells, proximal airway cells, CD8(+) T cells from bronchial lymph nodes (T-BL) and CD8(+) T cells from lungs (T-L). Key functional genes were identified with the aid of the reference library of the National Center for Biotechnology Information Gene Expression Omnibus database. Seventeen genes were up-regulated and 56 genes were down-regulated in chromosome 4 of TCs compared with other cells. Four genes (Akap2, Gpr153, Sdc3 and Tbc1d2) were up-regulated between one and fourfold and one gene, Svep1, was overexpressed over fourfold. The main functional networks were identified and analysed, pointing out to a TCs involvement in cellular signalling, regulation of tissue inflammation and cell expansion and movement.
推荐引用方式
GB/T 7714：

Song Dongli,Cretoiu Dragos,Zheng Minghuan, et al. Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types [J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2016,20(1):71-80.
APA：

Song Dongli,Cretoiu Dragos,Zheng Minghuan,Qian Mengjia,&Wang Xiangdong.(2016).Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,20(1):71-80.
MLA：

Song Dongli, et al. "Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types" .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 20,1(2016):71-80.

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