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Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis 期刊论文

编号：

863e02b1-0933-4ccb-acc7-611e7926de80
作者：

Li, Bao^[1];Peng, YuBing^[1];Chen, Qi^[1];Zhou, Juan^[1];Zhang, Ming^[1];Wang, Hao^[1];Li, WenJi^[1];Da, Jun^[1];Wang, Zhong^[1];Gao, Yan(高岩)^[2]
语种：

English
期刊：

FRONTIERS IN BIOSCIENCE-LANDMARK ISSN：1093-9946 2015 年 20 卷 (716 - 727) ; JAN 1
收录：
关键词：

Prostate Normal Cancer Peripheral Zone PSCs TSCs
摘要：

The human prostate contains two types of stromal cells, peripheral stromal cells (PSCs) and transitional stromal cells (TSCs). Here, we demonstrate the effects of PSCs and TSCs on tumorigenesis in prostate cancer (PCa) and identify the mechanisms underlying these effects. Using microarray analysis, we identified 3,643 differentially expressed genes in cocultures of TSCs, PSCs, and DU145 cells, a human prostate cancer cell line. Expression of cell division cycle 25 homolog A (CDC25A) was lower and that of tumor-associated calcium signal transducer 2 (TACSTD2) was higher in TSCs than in PSCs. Additionally, increased CDC25A expression or decreased TACSTD2 expression modulated the survival, growth, and migration of DU145 cells. These data suggest that PSCs promote and TSCs inhibit tumorigenesis by regulating the expression of CDC25A and TACSTD2.
推荐引用方式
GB/T 7714：

Li Bao,Peng Yu-Bing,Chen Qi, et al. Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis [J].FRONTIERS IN BIOSCIENCE-LANDMARK,2015,20:716-727.
APA：

Li Bao,Peng Yu-Bing,Chen Qi,Zhou Juan,&Gao Yan.(2015).Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis .FRONTIERS IN BIOSCIENCE-LANDMARK,20:716-727.
MLA：

Li Bao, et al. "Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis" .FRONTIERS IN BIOSCIENCE-LANDMARK 20(2015):716-727.

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