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Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case-control study in Xinjiang, China 期刊论文

编号：

889831b4-2774-4757-8b52-e437e17a384b
作者：

Cui, Meng^[1,2];Fang, Qiwen^[3];Zheng, Jun^[4];Shu, Zhanjun^[5,6];Chen, Yin^[6];Fan, Yage^[1,2];Zhao, Juan^[1,2];Wood, Charles^[7,8];Zhang, Tiejun(张铁军)*^[3]Zeng, Yan^[1,2];
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES ISSN：1201-9712 2019 年 80 卷 (73 - 79) ; MAR
收录：
关键词：

Antibodies Diabetes mellitus, type 2 Herpesvirus 8, human Seroepidemiological studies Viral load
摘要：

Objective: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China.
Methods: A case-control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures.
Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% confidence interval (CI) 43.6-54.5%) for diabetic patients and 23.7% (95% CI 19.4-28.0%) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95% CI 2.05-4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95% CI 1.21-1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95% CI 2.25-4.75; lytic: OR 3.99, 95% CI 2.68-5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p < 0.001).
Conclusions: Patients with DM-2 have an elevated risk of KSHV infection. Both antibody titers and viral load increased with blood glucose levels. (c) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
推荐引用方式
GB/T 7714：

Cui Meng,Fang Qiwen,Zheng Jun, et al. Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case-control study in Xinjiang, China [J].INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2019,80:73-79.
APA：

Cui Meng,Fang Qiwen,Zheng Jun,Shu Zhanjun,&Zeng Yan.(2019).Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case-control study in Xinjiang, China .INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,80:73-79.
MLA：

Cui Meng, et al. "Kaposi's sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case-control study in Xinjiang, China" .INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 80(2019):73-79.
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