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Lower Serum Soluble-EGFR Is a Potential Biomarker for Metastasis of HCC Demonstrated by N-glycoproteomic Analysis 期刊论文

编号：

88f9e241-91c6-4e00-bbf5-49b22e34bdfb
作者：

Hu, Heng^[1];Gao, Lingling^[1];Wang, Cun(王存)^[2,3]Li, Yan(李雁)^[2,3]Ma, Huiying^[1];Chen, Long(陈龙)^[1]Qin, Jie^[1];Liu, Binbin^[2];Liu, Yinkun(刘银坤)^[2,3]Liang, Chunmin(梁春敏)^[1]
语种：

English
期刊：

DISCOVERY MEDICINE ISSN：1539-6509 2015 年 19 卷 106 期 (333 - 341) ; MAY
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摘要：

Hepatocellular carcinoma (HCC) is one of the most deadly cancers in the world due to its high metastatic potential. By using the isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative N-glycoproteomic analysis, 26 differentially expressed serum glycoproteins derived from defined stages in orthotopic xenograft tumor model were identified. Among them, expression level of soluble EGFR (sEGFR) was verified in HCC cell lines. We found that non-metastasis HCC cell lines express significantly more sEGFR than HCC cell lines with metastasis potential both in cell lysates and culture media. Serum samples from 28 non-metastatic HCC patients and 28 metastatic HCC patients were assayed. Compared with the non-metastatic HCC group, serum level of sEGFR in metastatic HCC group was statistically lower (p<0.01). All these results provide evidence that sEGFR is a potential candidate for metastasis-associated biomarkers of HCC. The related molecular mechanism deserves to be further explored.
推荐引用方式
GB/T 7714：

Hu Heng,Gao Lingling,Wang Cun, et al. Lower Serum Soluble-EGFR Is a Potential Biomarker for Metastasis of HCC Demonstrated by N-glycoproteomic Analysis [J].DISCOVERY MEDICINE,2015,19(106):333-341.
APA：

Hu Heng,Gao Lingling,Wang Cun,Li Yan,&Liang Chunmin.(2015).Lower Serum Soluble-EGFR Is a Potential Biomarker for Metastasis of HCC Demonstrated by N-glycoproteomic Analysis .DISCOVERY MEDICINE,19(106):333-341.
MLA：

Hu Heng, et al. "Lower Serum Soluble-EGFR Is a Potential Biomarker for Metastasis of HCC Demonstrated by N-glycoproteomic Analysis" .DISCOVERY MEDICINE 19,106(2015):333-341.

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