首页 / 院系成果 / 成果详情页

Increased expression of TGFβR2 Is associated with the clinical outcome of non-small cell lung cancer patients treated with chemotherapy 期刊论文

编号：

893c4d07-8d88-4ced-a9d7-3de2a2dedeff
作者：

Han, Yang[0]^[1] Jia, Chengyou[1]^[2] Cong, Xianling[2]^[3] Yu, Fei[3]^[4] Cai, Haidong[4]^[2] Fang, Suyun[5]^[2] Cai, Li[6]^[5] Yang, Huiqiong[7]^[6] Sun, Yu[8]^[7] Li, Dan[9]^[2] Liu, Jin[10]^[2] Xie, Ruting[11]^[6] Yuan, Xueyu[12]^[2] Zhong, Xiaoming[13]^[8] Li, Ming[14]^[9] Wei, Qing[15]^[10] Lv, Zhongwei[16]^[2] Fu, Da[17]^[2] Ma, Yushui[18]^[2]
地址：

[1]Inner Mongolia Medical University, Department of Radiology,,China
[2]Tongji University, Department of Nuclear Medicine,Shanghai,China
[3]Jilin University, China-Japan Union Hospital,Changchun,China
[4]Shanghai Institute of Technology, College of Chemistry and Environmental Engineering,Shanghai,China
[5]Harbin Medical University, The Fourth Department of Medical Oncology,Harbin,China
[6]Hunan Agricultural University, College of Veterinary Medicine,Changsha,China
[7]Huashan Hospital, Department of Nuclear Medicine,Shanghai,China
[8]Jiangxi Provincial Tumor Hospital, Department of Radiology,Beijing,China
[9]Fudan University, Department of Radiology,Shanghai,China
[10]Tongji University, Department of Pathology,Shanghai,China
语种：

英文
期刊：

PLoS ONE ISSN：1932-6203 2015 年 10 卷 8 期
收录：
摘要：

To investigate the prognostic significance of TGFβR2 expression and chemotherapy in Chinese non-small cell lung cancer (NSCLC) patients, TGFβR2 expression NSCLC was analyzed in silico using the Oncomine database, and subsequently analyzed with quantitative RT-PCR in 308 NSCLC biopsies, 42 of which were paired with adjacent non-neoplastic tissues. Our results show that TGFβR2 expression was also increased in NSCLC biopsies relative to normal tissue samples and correlated with poor prognosis. TGFβR2 expression was also significantly correlated with other clinical parameters such as tumor differentiation, invasion of lung membrane, and chemotherapy. Moreover, overall survival (OS) and disease free survival (DFS) was increased in patients with low TGFβR2 expressing NSCLC and who had undergone chemotherapy. Thus, high expression of TGFβR2 is a significant risk factor for decreased OS and DFS in NSCLC patients. Thus, TGFβR2 is a potential prognostic tumor biomarker for chemotherapy. Copyright: ? 2015 Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
推荐引用方式
GB/T 7714：

Han Yang/56864843600[0],Jia Chengyou/35214925200[1],Cong Xianling/15831159900[2], et al. Increased expression of TGFβR2 Is associated with the clinical outcome of non-small cell lung cancer patients treated with chemotherapy [J].PLoS ONE,2015,10(8).
APA：

Han Yang/56864843600[0],Jia Chengyou/35214925200[1],Cong Xianling/15831159900[2],Yu Fei/55059360200[3],&Ma Yushui/56434841400[18].(2015).Increased expression of TGFβR2 Is associated with the clinical outcome of non-small cell lung cancer patients treated with chemotherapy .PLoS ONE,10(8).
MLA：

Han Yang/56864843600[0], et al. "Increased expression of TGFβR2 Is associated with the clinical outcome of non-small cell lung cancer patients treated with chemotherapy" .PLoS ONE 10,8(2015).

浏览次数：3  下载次数：0

分享到：

浏览次数：3

下载次数：0

打印次数：0