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Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity 期刊论文

编号：

89a527cc-3c30-483e-86ae-ff3c4406f892
作者：

Yang, Chengbin^[1] Zhang, Xi^[2] Wang, Yi^[2] Yang, Yongtai^[1] Liu, Xiaofeng^[1] Deng, Mingli^[1] Jia, Yu^[1] Ling, Yun^[1] Meng, Linghua^[2] Zhou, Yaming^[1]
语种：

English
期刊：

ACS MEDICINAL CHEMISTRY LETTERS ISSN：1948-5875 2017 年 8 卷 8 期 (875 - 880) ; AUG
收录：
关键词：

PI3K PI3K/mTOR oncology 1H-pyrrolo[2,3-b] pyridine cancer therapy
摘要：

The phosphoinositide 3-kinase (PI3K) inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR, which provides a promising new approach for the molecularly targeted cancer therapy. In this work, a novel series of 7-azaindole scaffold derivatives was discovered by the fragment-based growing strategy. The structure-activity relationship profiles identified that the 7-azaindole scaffold derivatives exhibit potent activity against PI3K at molecular and cellular levels as well as cell proliferation in a panel of human tumor cells.
推荐引用方式
GB/T 7714：

Yang Chengbin,Zhang Xi,Wang Yi, et al. Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity [J].ACS MEDICINAL CHEMISTRY LETTERS,2017,8(8):875-880.
APA：

Yang Chengbin,Zhang Xi,Wang Yi,Yang Yongtai,&Zhou Yaming.(2017).Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity .ACS MEDICINAL CHEMISTRY LETTERS,8(8):875-880.
MLA：

Yang Chengbin, et al. "Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity" .ACS MEDICINAL CHEMISTRY LETTERS 8,8(2017):875-880.

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