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Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs 期刊论文

编号：

89c1d519-25e9-4dc8-8709-3f69e7f4de93
作者：

Chen, Xi^[1] Wen, Ti^[2,3] Wei, Jun^[2] Wu, Zhenzhou^[2] Wang, Puyue^[2] Hong, Zhangyong^[2] Zhao, Liqing^[2] Wang, Bin^[4] Flavell, Richard^[5] Gao, Shumei^[6] Wang, Min^[1] Yin, Zhinan^[2]
语种：

English
期刊：

CELLULAR & MOLECULAR IMMUNOLOGY ISSN：1672-7681 2013 年 10 卷 6 期 (497 - 505) ; NOV
收录：
关键词：

asthma bavachinin IL-4
摘要：

Asthmatic inflammation is mediated by a type 2 helper T cell (Th2) cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.
推荐引用方式
GB/T 7714：

Chen Xi,Wen Ti,Wei Jun, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs [J].CELLULAR & MOLECULAR IMMUNOLOGY,2013,10(6):497-505.
APA：

Chen Xi,Wen Ti,Wei Jun,Wu Zhenzhou,&Yin Zhinan.(2013).Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs .CELLULAR & MOLECULAR IMMUNOLOGY,10(6):497-505.
MLA：

Chen Xi, et al. "Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs" .CELLULAR & MOLECULAR IMMUNOLOGY 10,6(2013):497-505.

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