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Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice 期刊论文

编号：

8a59570c-b8af-40d7-9ac8-a60c202f7eb1
作者：

Xue, Feng[0];Wang, Li[1];Liu, Yue[2];Tang, Haiping[3];Xu, Wanxiang[4];Xu, Chen[5];
地址：

Shanghai Jiao Tong University School of Medicine, Department of Anatomy,Shanghai,China[0];Shanghai Jiao Tong University School of Medicine, Department of Anatomy,Shanghai,China[1];Shanghai Jiaotong University, School of Medicine,Shanghai,China[2];Fudan University, Department of Reproductive Immunology,Shanghai,China[3];Fudan University, Department of Reproductive Immunology,Shanghai,China[4];Shanghai Jiao Tong University School of Medicine, Department of Anatomy,Shanghai,China[5];
语种：

英文
期刊：

American Journal of Reproductive Immunology ISSN：1046-7408 2016 年 75 卷 4 期 (474 - 485)
收录：
关键词：

IZUMO Linear B-cell epitope Peptide vaccine Sperm antigen Sperm-egg fusion
摘要：

Problem: The development of a new and suitable contraceptive methods, as well as in-depth and systematic research into underlying contraceptive mechanisms, is crucial. IZUMO1 plays an important role in the fusion of the sperm and ovum during fertilization. Izumo^-/- mice are infertile. Therefore, IZUMO1 may be a potential target for the development of a contraceptive vaccine. Method of study: Linear B-cell epitopes (BCE) were identified in IZUMO using biosynthetic peptides and used to immunize female mice. Results: Five IZUMO BCE were identified: DLVLDCL177-183, YSFYRV196-201 (named BCE-2), YLT217-219, SMVGPED221-227, and DAGNY228-232. Active immunization with the BCE-2 vaccine sharply decreased the fertility rate in female mice in a safe and reversible manner. In vitro fertilization showed that the BCE-2 vaccine interferes with and blocks the fusion of the sperm and the ovum. Conclusions: B-cell epitopes-2 may be a new candidate for the development of contraceptive vaccine due to its effectiveness, safety, and reversibility. ? 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
推荐引用方式
GB/T 7714：

Xue Feng[0],Wang Li[1],Liu Yue[2], et al. Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice [J].American Journal of Reproductive Immunology,2016,75(4):474-485.
APA：

Xue Feng[0],Wang Li[1],Liu Yue[2],Tang Haiping[3],&Xu Chen[5].(2016).Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice .American Journal of Reproductive Immunology,75(4):474-485.
MLA：

Xue Feng[0], et al. "Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice" .American Journal of Reproductive Immunology 75,4(2016):474-485.

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