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Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts 期刊论文

编号：

8ab28021-4604-4a8a-a516-c3be5504ccc9
作者：

Zheng, Xiangpeng^[1,2] Goins, Beth A.^[2] Cameron, Ivan L.^[3] Santoyo, Cristina^[2] Bao, Ande^[2] Frohlich, Victoria C.^[4] Fullerton, Gary D.^[2]
语种：

English
期刊：

CANCER CHEMOTHERAPY AND PHARMACOLOGY ISSN：0344-5704 2011 年 67 卷 1 期 (173 - 182) ; JAN
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关键词：

Solid tumor Interstitial fluid pressure Collagenase Drug delivery Liposome
摘要：

Purpose To investigate the effect of intratumoral administration of collagenase-2 on liposomal drug accumulation and diffusion in solid tumor xenografts. Methods Correlation between tumor interstitial fluid pressure (IFP) and tumor physiological properties (size and vessel fraction by B-mode and Doppler ultrasound, respectively) was determined. IFP response to intravenous or intratumoral collagenase-2 (0.1%) treatment was compared with intratumoral deactivated collagenase-2. To evaluate drug accumulation and diffusion, technetium-99 m-((99m)Tc)-liposomal doxorubicin (Doxil((TM))) was intravenously injected after collagenase-2 (0.1 and 0.5%, respectively) treatment, and planar scintigraphic images acquired and percentage of the injected dose per gram tissue calculated. Subsequently, tumors were subjected to autoradiography and histopathology. Results IFP in two-week-old head and neck squamous cell carcinoma xenografts was 18 +/- 3.7 mmHg and not correlated to the tumor size but had reverse correlation with the vessel fraction (r = -0.91, P < 0.01). Intravenous and intratumoral collagenase-2 use reduced IFP by a maximum of 35-40%. Compared to the control, the low IFP level achieved through intratumoral route remained for a long period (24 vs. 2 h, P < 0.05). SPECT images and autoradiography showed significantly higher (99m)Tc-Doxil (TM) accumulation in tumors with intratumoral collagenase-2 treatment, confirmed by %ID/g in tumors (P < 0.05), and pathological findings showed extensive distribution of Doxil (TM) in tumors. Conclusions Intratumoral injection of collagenase-2 could effectively reduce IFP in HNSCC xenografts for a longer period than using intravenous approach, which allowed for more efficient accumulation and homogeneous diffusion of the Doxil (TM) within the tumor interstitium.
推荐引用方式
GB/T 7714：

Zheng Xiangpeng,Goins Beth A.,Cameron Ivan L., et al. Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts [J].CANCER CHEMOTHERAPY AND PHARMACOLOGY,2011,67(1):173-182.
APA：

Zheng Xiangpeng,Goins Beth A.,Cameron Ivan L.,Santoyo Cristina,&Fullerton Gary D..(2011).Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts .CANCER CHEMOTHERAPY AND PHARMACOLOGY,67(1):173-182.
MLA：

Zheng Xiangpeng, et al. "Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts" .CANCER CHEMOTHERAPY AND PHARMACOLOGY 67,1(2011):173-182.

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