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Role of elevated red cell distribution width on acute kidney injury patients after cardiac surgery 期刊论文

编号：

8abd1a3c-61cb-4e52-bb2e-452f7a22ece7
作者：

Zou, Zhouping^[1,2,3,4];Zhuang, Yamin^[5];Liu, Lan^[5];Shen, Bo(沈波)^[1,2,3,4]Xu, Jiarui(许佳瑞)^[1,3,4]Jiang, Wuhua(姜物华)^[1,3,4]Luo, Zhe^[5];Teng, Jie(滕杰)*^{[1,2,3,4,6,7]}Wang, Chunsheng(王春生)^[8]Ding, Xiaoqiang(丁小强)*^{[1,2,3,4,6,7]}
语种：

English
期刊：

BMC CARDIOVASCULAR DISORDERS ISSN：1471-2261 2018 年 18 卷 ; AUG 14
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关键词：

Acute kidney injury Cardiac surgery Prognosis Red cell distribution width
摘要：

Background: The aim of the study was to explore associations between elevated red cell distribution width (RDW) and acute kidney injury (AKI) in patients undergoing cardiac surgery (CS-AKI). Methods: Preoperative, intraoperative and postoperative data of 10,274 patients undergoing cardiac surgery, including demographic data, were prospectively collected from January 2009 to December 2014. Propensity score matching was used on the basis of clinical characteristics and preoperative variables. An elevated RDW was defined as the difference between RDW 24 h after cardiac surgery and the latest RDW before cardiac surgery. Results: A total of 10,274 patients were included in the unmatched cohort, and 3146 patients in the propensity-matched cohort. In the unmatched cohort, the overall CS-AKI incidence was 32.8% (n = 3365) with a hospital mortality of 5.5% (n = 185). In the propensity-matched cohort, the elevated RDW in AKI patients was higher than in patients without AKI (0.3% (0.0%, 0.7%) vs 0.5% (0.1, 1.1%), P < 0.001) and the elevated RDW incidences were 0.4% (0.1%, 0.9%), 0.6% (0.2%, 1.1%) and 1.1% (0.3%, 2.1%) in stage 1, 2 and 3 AKI patients (P < 0.001). Among propensity-matched patients with CS-AKI, the level of elevated RDW in non-survivors was higher than in survivors [1.2% (0.5%, 2.3%) vs 0.5% (0.1%, 1.0%), P < 0.001] and a 0.1% increase in elevated RDW was associated with a 0.24% higher risk of within-hospital mortality in patients with CS-AKI. Estimating the receiver-operating characteristic (ROC) area under the curve (AUC) showed that an elevated RDW had moderate discriminative power for AKI development (AUC = 0.605, 95% CI, 0.586-0.625; P < 0.001) and hospital mortality (AUC = 0.716, 95% CI, 0.640-0.764; P < 0.001) in the propensity-matched cohort. Conclusions: An elevated RDW might be an independent prognostic factor for the severity and poor prognosis of CS-AKI.
推荐引用方式
GB/T 7714：

Zou Zhouping,Zhuang Yamin,Liu Lan, et al. Role of elevated red cell distribution width on acute kidney injury patients after cardiac surgery [J].BMC CARDIOVASCULAR DISORDERS,2018,18.
APA：

Zou Zhouping,Zhuang Yamin,Liu Lan,Shen Bo,&Ding Xiaoqiang.(2018).Role of elevated red cell distribution width on acute kidney injury patients after cardiac surgery .BMC CARDIOVASCULAR DISORDERS,18.
MLA：

Zou Zhouping, et al. "Role of elevated red cell distribution width on acute kidney injury patients after cardiac surgery" .BMC CARDIOVASCULAR DISORDERS 18(2018).

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