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Animal behavioral assessments in current research of Parkinson's disease 期刊论文

编号：

8b48867f-ba2e-4cea-8fb3-45baf63be738
作者：

Asakawa, Tetsuya^[1,2];Fang, Huan(方欢)^[3]Sugiyama, Kenji^[1];Nozaki, Takao^[1];Hong, Zhen(洪震)^[4]Yang, Yilin^[5];Hua, Fei^[5];Ding, Guanghong^[6];Chao, Dongman^[7];Fenoy, Albert J.^[7];Villarreal, Sebastian J.^[7];Onoe, Hirotaka^[8];Suzuki, Katsuaki^[2];Mori, Norio^[2];Namba, Hiroki^[1];Xia, Ying^[7];
语种：

English
期刊：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS ISSN：0149-7634 2016 年 65 卷 (63 - 94) ; JUN
收录：
关键词：

Behavioral assessments Fine motor Free-moving counting Food reaching movement Locomotion motor symptoms Non-motor symptoms Parkinsonian model Neuropsychological tasks
摘要：

Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Asakawa Tetsuya,Fang Huan,Sugiyama Kenji, et al. Animal behavioral assessments in current research of Parkinson's disease [J].NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2016,65:63-94.
APA：

Asakawa Tetsuya,Fang Huan,Sugiyama Kenji,Nozaki Takao,&Xia Ying.(2016).Animal behavioral assessments in current research of Parkinson's disease .NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,65:63-94.
MLA：

Asakawa Tetsuya, et al. "Animal behavioral assessments in current research of Parkinson's disease" .NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 65(2016):63-94.

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