Objective. Previous research on treatment of lipoid proteinosis has focused on genetic etiology and clinical diagnosis of this rare laryngeal disorder. However, few studies on this disorder have examined treatment methods directed at improving voice qualities. The purpose of this study was to examine a novel hybrid treatment approach and its improvements in the patient's voice quality. Study Design and Methods. In this case study, a 27-year-old man complaining of hoarseness of voice and effortful phonation was diagnosed with lipoid proteinosis. He was then prescribed a combination of surgical intervention and voice therapy to improve his overall voice quality. Results. The results of the posttreatment evaluation demonstrate significant improvements in both objective and subjective voice quality measurements. Conclusion. A further examination of this hybrid approach in the treatment of lipoid proteinosis is warranted to determine its efficacy.