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Intra-amniotic Injection of Mouse Embryos 期刊论文

编号：

8c9f1a6c-d9ca-470a-9f29-12736908ac25
作者：

Cui, Liyuan;Zou, Peng;Meng, Qingshuo;Lu, Lu^[1];Zhang, Jiayi(张嘉漪)*^[1]
语种：

英文
期刊：

BIO-PROTOCOL ISSN：2331-8325 2018 年 8 卷 10 期 ; MAY 20
收录：
关键词：

Intra-amniotic Embryos Virus Infection
摘要：

Recent outbreaks of infectious neuro-developmental diseases such as congenital Zika syndrome - have led to a demand for prognosis data from animal models. We developed an intra-amniotic injection mice model that allows Zika virus (ZIKV) infected mice to grow to puberty. In this system, ZIKV is injected into the amniotic fluid of pregnant mice and infected embryos thereafter. ZIKV-infected mice show several symptoms of clinical 'congenital Zika syndrome', including decreased brain volume and mis-laminated retina. We also evaluated several behavioral functions of these ZIKV-infected mice, for example, after the mice reach puberty, they have visual and motor defects. This technique can be used to screen and evaluate drug candidates and may help evaluate the prognosis of infectious neuro-developmental diseases.
推荐引用方式
GB/T 7714：

Cui Liyuan,Zou Peng,Meng Qingshuo, et al. Intra-amniotic Injection of Mouse Embryos [J].BIO-PROTOCOL,2018,8(10).
APA：

Cui Liyuan,Zou Peng,Meng Qingshuo,Lu Lu,&Zhang Jiayi.(2018).Intra-amniotic Injection of Mouse Embryos .BIO-PROTOCOL,8(10).
MLA：

Cui Liyuan, et al. "Intra-amniotic Injection of Mouse Embryos" .BIO-PROTOCOL 8,10(2018).

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