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SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression 期刊论文

编号：

8d3ca992-3bdc-421b-a945-953b9b5baf98
作者：

Xu, Zhejun^[1];Liang, Qifei^[1];Song, Xiaolei^[1];Zhang, Zhuangzhi^[1];Lindtner, Susan^[2];Li, Zhenmeiyu^[1];Wen, Yan^[1];Liu, Guoping^[1];Guo, Teng^[1];Qi, Dashi^[1];Wang, Min^[1];Wang, Chunyang^[1];Li, Hao^[1];You, Yan^[1];Wang, Xin(汪昕)^[1]Chen, Bin^[3];Feng, Hua^[4];Rubenstein, John L.^[2];Yang, Zhengang(杨振纲)*^[1]
语种：

English
期刊：

DEVELOPMENT ISSN：0950-1991 2018 年 145 卷 14 期 ; JUL 15
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关键词：

Sp8 Sp9 Six3 LGE DRD2 Striatum Medium spiny neuron Mouse
摘要：

Dopamine receptor DRD1-expressing medium spiny neurons (D1 MSNs) and dopamine receptor DRD2-expressing medium spiny neurons (D2 MSNs) are the principal projection neurons in the striatum, which is divided into dorsal striatum (caudate nucleus and putamen) and ventral striatum (nucleus accumbens and olfactory tubercle). Progenitors of these neurons arise in the lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking the transcription factor genes Sp8 and Sp9 lose virtually all D2 MSNs as a result of reduced neurogenesis in the LGE, whereas D1 MSNs are largely unaffected. SP8 and SP9 together drive expression of the transcription factor Six3 in a spatially restricted domain of the LGE subventricular zone. Conditional deletion of Six3 also prevents the formation of most D2 MSNs, phenocopying the Sp8/9 mutants. Finally, ChIP-Seq reveals that SP9 directly binds to the promoter and a putative enhancer of Six3. Thus, this study defines components of a transcription pathway in a regionally restricted LGE progenitor domain that selectively drives the generation of D2 MSNs.
推荐引用方式
GB/T 7714：

Xu Zhejun,Liang Qifei,Song Xiaolei, et al. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression [J].DEVELOPMENT,2018,145(14).
APA：

Xu Zhejun,Liang Qifei,Song Xiaolei,Zhang Zhuangzhi,&Yang Zhengang.(2018).SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression .DEVELOPMENT,145(14).
MLA：

Xu Zhejun, et al. "SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression" .DEVELOPMENT 145,14(2018).

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