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In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment 期刊论文 WOS高被引论文

编号：

8d5a0c7a-bc2c-4701-9876-f77e1b72bb7b
作者：

Chen, Qian^[1,2,3,4];Wang, Chao^[3,4];Zhang, Xudong^[1,2];Chen, Guojun^[1,2];Hu, Quanyin^[1,2,3,4];Li, Hongjun^[5,6];Wang, Jinqiang^[3,4];Wen, Di^[1,2];Zhang, Yuqi^[3,4];Lu, Yifei^[3,4,7];Yang, Guang^[1,2];Jiang, Chen(蒋晨)^[7]Wang, Jun^[5,6];Dotti, Gianpietro^[8];Gu, Zhen^{[1,2,3,4,9,10]};
语种：

英文
期刊：

NATURE NANOTECHNOLOGY ISSN：1748-3387 2019 年 14 卷 1 期 (89 - +) ; JAN
收录：
摘要：

Cancer recurrence after surgical resection remains a significant cause of treatment failure. Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that controls both local tumour recurrence after surgery and development of distant tumours. Briefly, calcium carbonate nanoparticles pre-loaded with the anti-CD47 antibody are encapsulated in the fibrin gel and scavenge H+ in the surgical wound, allowing polarization of tumour-associated macrophages to the M1-like phenotype. The released anti-CD47 antibody blocks the 'don't eat me' signal in cancer cells, thereby increasing phagocytosis of cancer cells by macrophages. Macrophages can promote effective antigen presentation and initiate T cell mediated immune responses that control tumour growth. Our findings indicate that the immunotherapeutic fibrin gel 'awakens' the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.
推荐引用方式
GB/T 7714：

Chen Qian,Wang Chao,Zhang Xudong, et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment [J].NATURE NANOTECHNOLOGY,2019,14(1):89-+.
APA：

Chen Qian,Wang Chao,Zhang Xudong,Chen Guojun,&Gu Zhen.(2019).In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment .NATURE NANOTECHNOLOGY,14(1):89-+.
MLA：

Chen Qian, et al. "In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment" .NATURE NANOTECHNOLOGY 14,1(2019):89-+.
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