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Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth 期刊论文

编号：

8ea83cb7-0436-4b3a-913f-574228a7b38f
作者：

Xia, Siyuan^[1];Lin, Ruiting^[1];Jin, Lingtao^[1];Zhao, Liang^[1];Kang, HeeBum^[1];Pan, Yaozhu^[1];Liu, Shuangping^[1];Qian, Guoqing^[1];Qian, Zhiyu^[1];Konstantakou, Evmorfia^[1];Zhang, Baotong^[1];Dong, JinTang^[1];Chung, Young Rock^[3];AbdelWahab, Omar^[3];Merghoub, Taha^[3];Zhou, Lu^[4];Kudchadkar, Ragini R.^[1];Lawson, David H.^[1];Khoury, Hanna J.^[1];Khuri, Fadlo R.^[1];Boise, Lawrence H.^[1];Lonial, Sagar^[1];Lee, Benjamin H.^[5];Pollack, Brian P.^[6,7];Arbiser, Jack L.^[6,7];Fan, Jun^[2];Lei, QunYing(雷群英)*^[4]Chen, Jing^[1];
语种：

English
期刊：

CELL METABOLISM ISSN：1550-4131 2017 年 25 卷 2 期 (358 - 373) ; FEB 7
收录：
摘要：

Lifestyle factors, including diet, play an important role in the survival of cancer patients. However, the molecular mechanisms underlying pathogenic links between diet and particular oncogenic mutations in human cancers remain unclear. We recently reported that the ketone body acetoacetate selectively enhances-BRAF V600Emutant-dependentMEK1 activation in human cancers. Here we show that a high-fat ketogenic diet increased serum levels of acetoacetate, leading to enhanced tumor growth potential of BRAF V600E-expressing human melanoma cells in xenograft mice. Treatment with hypolipidemic agents to lower circulating acetoacetate levels or an inhibitory homolog of acetoacetate, dehydroacetic acid, to antagonize acetoacetate-BRAF V600E binding attenuatedBRAF V600E tumor growth. These findings reveal a signaling basis underlying a pathogenic role of dietary fat in BRAF V600E-expressing melanoma, providing insights into the design of conceptualized "precisiondiets'' that may prevent or delay tumor progression based on an individual's specific oncogenic mutation profile.
推荐引用方式
GB/T 7714：

Xia Siyuan,Lin Ruiting,Jin Lingtao, et al. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth [J].CELL METABOLISM,2017,25(2):358-373.
APA：

Xia Siyuan,Lin Ruiting,Jin Lingtao,Zhao Liang,&Chen Jing.(2017).Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth .CELL METABOLISM,25(2):358-373.
MLA：

Xia Siyuan, et al. "Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth" .CELL METABOLISM 25,2(2017):358-373.

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