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Riboflavin Biosynthetic and Regulatory Factors as Potential Novel Anti-Infective Drug Targets 期刊论文

编号：

918b81ca-8c25-4923-94cd-51e5de5dc95d
作者：

Long, Quanxin^[1] Ji, Lei^[1] Wang, Honghai^[2] Xie, Jianping^[1,2]
语种：

English
期刊：

CHEMICAL BIOLOGY & DRUG DESIGN ISSN：1747-0277 2010 年 75 卷 4 期 (339 - 347) ; APR
收录：
关键词：

drug discovery drug lead riboflavin synthesis riboswitch
摘要：

Riboflavin (vitamin B-2) is the direct precursor of redox enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for multiple cell physiology. The riboflavin biosynthetic pathway is regarded as a rich resource for therapeutic targets for broad spectrum antibiotics. Enzymatic pathways, regulatory factors of the riboflavin biosynthesis, and relevant drug discovery are summarized in this review. The novel riboswitch regulatory mechanism of riboflavin metabolism is also described. A compendium of chemical modulators of riboflavin biosynthesis and regulatory networks is listed and such demonstrates the promise of riboflavin biosynthesis and regulatory mechanisms as potential therapeutic targets for novel antibiotic drug discovery.
推荐引用方式
GB/T 7714：

Long Quanxin,Ji Lei,Wang Honghai, et al. Riboflavin Biosynthetic and Regulatory Factors as Potential Novel Anti-Infective Drug Targets [J].CHEMICAL BIOLOGY & DRUG DESIGN,2010,75(4):339-347.
APA：

Long Quanxin,Ji Lei,Wang Honghai,Xie Jianping.(2010).Riboflavin Biosynthetic and Regulatory Factors as Potential Novel Anti-Infective Drug Targets .CHEMICAL BIOLOGY & DRUG DESIGN,75(4):339-347.
MLA：

Long Quanxin, et al. "Riboflavin Biosynthetic and Regulatory Factors as Potential Novel Anti-Infective Drug Targets" .CHEMICAL BIOLOGY & DRUG DESIGN 75,4(2010):339-347.

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