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Targeting IRF3 as a YAP agonist therapy against gastric cancer 期刊论文

编号：

92205477-5151-481d-958c-ece017c85956
作者：

Jiao, Shi^[1];Guan, Jingmin^[1];Chen, Min^[1];Wang, Wenjia^[1];Li, Chuanchuan^[1];Wang, Yugong^[2];Cheng, Yunfeng(程韵枫)^[3,4]Zhou, Zhaocai^[1,2];
语种：

English
期刊：

JOURNAL OF EXPERIMENTAL MEDICINE ISSN：0022-1007 2018 年 215 卷 2 期 (699 - 718) ; FEB
收录：
摘要：

The Hippo pathway plays a vital role in tissue homeostasis and tumorigenesis. The transcription factor IRF3 is essential for innate antiviral immunity. In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the expression of both IRF3 and YAP is up-regulated and prognosticates patient survival. IRF3 interacts with both YAP and TEAD4 in the nucleus to enhance their interaction, promoting nuclear translocation and activation of YAP. IRF3 and YAP-TEAD4 are associated genome-wide to cobind and coregulate many target genes of the Hippo pathway. Overexpression of active IRF3 increased, but depletion of IRF3 reduced, the occupancy of YAP on the target genes. Knockdown or pharmacological targeting of IRF3 by Amlexanox, a drug used clinically for antiinflammatory treatment, inhibits gastric tumor growth in a YAP-dependent manner. Collectively, our study identifies IRF3 as a positive regulator for YAP, highlighting a new therapeutic target against YAP-driven cancers.
推荐引用方式
GB/T 7714：

Jiao Shi,Guan Jingmin,Chen Min, et al. Targeting IRF3 as a YAP agonist therapy against gastric cancer [J].JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(2):699-718.
APA：

Jiao Shi,Guan Jingmin,Chen Min,Wang Wenjia,&Zhou Zhaocai.(2018).Targeting IRF3 as a YAP agonist therapy against gastric cancer .JOURNAL OF EXPERIMENTAL MEDICINE,215(2):699-718.
MLA：

Jiao Shi, et al. "Targeting IRF3 as a YAP agonist therapy against gastric cancer" .JOURNAL OF EXPERIMENTAL MEDICINE 215,2(2018):699-718.

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