首页 / 院系成果 / 成果详情页

HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients 期刊论文

编号：

92aa4641-4a5b-4bc1-82ec-0e582b757b5a
作者：

Feng, Xuelin#^[1]Li, Wenhui(李文辉)#^[2]Song, Jie(宋捷)^[1]Liu, Xiaoni^[3];Gu, Yuehua^[3];Yan, Chong^[1];Wu, Hui^[4];Xi, Jianying(奚剑英)^[1]Zhou, Shuizhen(周水珍)*^[2]Zhao, Chongbo(赵重波)*^[1,4]
语种：

英文
期刊：

JOURNAL OF CLINICAL NEUROSCIENCE ISSN：0967-5868 2019 年 59 卷 (179 - 184) ; JAN
收录：
关键词：

Myasthenia gravis Human leukocyte antigen Next generation sequencing Juvenile-onset myasthenia gravis
摘要：

To compare HLA typing between juvenile- and adult-onset myasthenia gravis (MG), we enrolled 101 children (age <= 12 years) and 168 adults (age >= 20 years) with MG. We excluded patients with histories of thymoma, thyroid disease, or other autoimmune disease. We selected 41 seronegative juvenile-onset patients with ocular symptoms only, and 41 seropositive adult-onset patients with generalized symptoms. We used next-generation sequencing for typing and analysis of HLA genes (Loci: A, B, C, DPA1, DPB1, DQA1, DQB1 and DRB1). Haplotypes HLA-A(*)02:07:01-B(*)46:01:01-C(*)01:02:01-DQA1(*)01:01:01-D QB1(*)03:03:02-DRB1(*)09:01:02, HLA-A(*)11:01:01, HLA-A(*)24:02:01, and HLA-DPA1(*)02:02:02 were found to be related to juvenile-onset MG and HLA-A(*)01:01:01, HLA-A(*)02:03:01, HLA-C(*)03:04:01, and HLA-DQB1(*)06:02:01 to adult-onset MG. Therefore, our findings suggested that HLA typing might determine the heterogeneity between AChR-Ab negative juvenile-onset and AChR-Ab positive adult-onset Chinese MG patients. (C) 2018 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Feng Xuelin,Li Wenhui,Song Jie, et al. HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients [J].JOURNAL OF CLINICAL NEUROSCIENCE,2019,59:179-184.
APA：

Feng Xuelin,Li Wenhui,Song Jie,Liu Xiaoni,&Zhao Chongbo.(2019).HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients .JOURNAL OF CLINICAL NEUROSCIENCE,59:179-184.
MLA：

Feng Xuelin, et al. "HLA typing using next-generation sequencing for Chinese juvenile- and adult-onset myasthenia gravis patients" .JOURNAL OF CLINICAL NEUROSCIENCE 59(2019):179-184.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：20  下载次数：0

分享到：

浏览次数：20

下载次数：0

打印次数：0