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Isolation and characterization of a novel noncoding RNA from nickel-induced lung cancer 期刊论文

编号：

931b591d-7b9c-4647-b6d1-b2612239952d
作者：

Zhang, Jun[0]^[1] Zhang, Jing[1]^[2] Zhou, Yang[2]^[3] Wu, Youjun[3]^[4] Ma, Lin[4]^[5] Fan, Yingying[5]^[6] Kang, Xuan[6]^[4] Shi, Hongjun[7]^[6]
地址：

[1]Tongji University, Department of Laboratory Medicine,Shanghai,China
[2]Second Affiliated Hospital of Harbin Medical University, Department of Surgery,Harbin,China
[3]Fudan University School of Life Sciences,Shanghai,China
[4]Tongji University,Shanghai,China
[5]Tongji University, Department of Neurology,Shanghai,China
[6]Tongji University, Department of Regenerative Medicine,Shanghai,China
语种：

英文
期刊：

Biological Trace Element Research ISSN：0163-4984 2012 年 150 卷 2017/1/3 期 (258 - 263)
收录：
关键词：

ADAMTS6 LINE1 Nickel Noncoding RNA
摘要：

Noncoding RNAs have drawn significant attention in carcinogenesis. In this study, we identified a novel gene named nickel-related gene1 (NRG1) associated with nickel-induced cancer. By using rapid amplification of cDNA end PCR, we obtained the full length of the cDNA. The sequence was analyzed by using related bioinformatics software and comparative genomics methods. The results showed that NRG1 was located on chromosome 2q12, within intron2 of ADAMTS6, a disintegrin and metalloproteinase with thrombospondin motifs. And, NRG1 had a high level of homology (76 %) to rat LINE1 sequence RL1.3 (long interspersed middle repetitive DNA). What"s more, there was no continuous open reading frame present in NRG1 sequence. Taken together, these data demonstrate that NRG1 is a novel noncoding RNA, and we predicted it may be a transposon-like gene. The identification of NRG1 emphasized the potential role of noncoding RNA in nickel carcinogenesis. © 2012 Springer Science+Business Media, LLC.
推荐引用方式
GB/T 7714：

Zhang Jun/54931447800[0],Zhang Jing/14025100800[1],Zhou Yang/57191652322[2], et al. Isolation and characterization of a novel noncoding RNA from nickel-induced lung cancer [J].Biological Trace Element Research,2012,150(2017/1/3):258-263.
APA：

Zhang Jun/54931447800[0],Zhang Jing/14025100800[1],Zhou Yang/57191652322[2],Wu Youjun/52564593200[3],&Shi Hongjun/55234758600[7].(2012).Isolation and characterization of a novel noncoding RNA from nickel-induced lung cancer .Biological Trace Element Research,150(2017/1/3):258-263.
MLA：

Zhang Jun/54931447800[0], et al. "Isolation and characterization of a novel noncoding RNA from nickel-induced lung cancer" .Biological Trace Element Research 150,2017/1/3(2012):258-263.

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