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Lugrandoside attenuates LPS-induced acute respiratory distress syndrome by anti-inflammation and anti-apoptosis in mice 期刊论文

编号：

93abf233-e4b4-413b-b696-48f5e8ee0af6
作者：

Li, Chengbao^[1,2];Huang, Ying^[4,5];Yao, Xueya^[2];Hu, Baoji(胡宝吉)^[6]Wu, Suzhen^[7];Chen, Guannan^[1];Lv, Xin^[1,3,4,5];Tian, Fubo^[8];
语种：

English
期刊：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH ISSN：1943-8141 2016 年 8 卷 12 期 (5557 - 5568)
收录：
关键词：

Acute respiratory distress syndrome anti-apoptosis anti-inflammation lipopolysaccharide lugrando-side
摘要：

This study aimed to investigate the protective effects and specific mechanisms of lugrandoside (LG) on lipopolysaccharides (LPS)-induced acute respiratory distress syndrome (ARDS). LG is a novel phenylpropanoid glycoside with many biological properties, isolated from the culinary leaves of Digitalis lutea L. and Digitalis grandiflora Miller. The primary indicators to assess the lung injury were infiltration of inflammatory cells; pulmonary edema; expression of proinflammatory cytokines, cyclo-oxygenase 2, and intracellular adhesion molecule 1; activation of nuclear factor-kappa B pathways; and cellular apoptosis. The results showed that LG evidently alleviated the inflammatory response, decreased the apoptosis of alveolar macrophages, and improved the lung injury in mice with LPS-induced ARDS. In conclusion, LG improved LPS-induced ARDS by anti-inflammation and anti-apoptosis and might be a promising pharmacological therapy for ARDS.
推荐引用方式
GB/T 7714：

Li Chengbao,Huang Ying,Yao Xueya, et al. Lugrandoside attenuates LPS-induced acute respiratory distress syndrome by anti-inflammation and anti-apoptosis in mice [J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2016,8(12):5557-5568.
APA：

Li Chengbao,Huang Ying,Yao Xueya,Hu Baoji,&Tian Fubo.(2016).Lugrandoside attenuates LPS-induced acute respiratory distress syndrome by anti-inflammation and anti-apoptosis in mice .AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,8(12):5557-5568.
MLA：

Li Chengbao, et al. "Lugrandoside attenuates LPS-induced acute respiratory distress syndrome by anti-inflammation and anti-apoptosis in mice" .AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 8,12(2016):5557-5568.

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