首页 / 院系成果 / 成果详情页

Radiotherapy-induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation 期刊论文

编号：

964d45ca-c53a-4b29-976f-fe64eeb255c3
作者：

Wang, Huiyong^[1];Zhang, Yanqing^[2];Qian, Jiang(钱江)^[2]Zhang, Mingui^[2];Wang, Xiangning^[2];
语种：

English
期刊：

MOLECULAR MEDICINE REPORTS ISSN：1791-2997 2013 年 8 卷 4 期 (1049 - 1054) ; OCT
收录：
关键词：

radiotherapy Gadd45a lacrimal gland epithelial cell
摘要：

Radiotherapy-induced lacrimal gland injury is a serious clinical problem currently lacking satisfactory therapeutic strategies. Exploring the mechanisms underlying secondary injuries caused by radiation may aid in the development of novel targeted medicine. In the current study, growth arrest and DNA damage-inducible 45 a (Gadd45a), a gene which is upregulated in irradiated skin, was observed as being overexpressed in the irradiated lacrimal gland. Moreover, overexpressed Gadd45a may impair lacrimal gland repair by inhibiting lacrimal gland epithelial cell migration and proliferation. Further signalling pathway analyses indicated that Gadd45a overexpression suppresses Akt (protein kinase B, PKB), P38 and JNK phosphorylation. Thus, the results of the current study suggested that Gadd45a may be a therapeutic target in radiation-induced lacrimal gland injury.
推荐引用方式
GB/T 7714：

Wang Huiyong,Zhang Yanqing,Qian Jiang, et al. Radiotherapy-induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation [J].MOLECULAR MEDICINE REPORTS,2013,8(4):1049-1054.
APA：

Wang Huiyong,Zhang Yanqing,Qian Jiang,Zhang Mingui,&Wang Xiangning.(2013).Radiotherapy-induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation .MOLECULAR MEDICINE REPORTS,8(4):1049-1054.
MLA：

Wang Huiyong, et al. "Radiotherapy-induced Gadd45a impairs lacrimal gland epithelial cell migration and proliferation" .MOLECULAR MEDICINE REPORTS 8,4(2013):1049-1054.

浏览次数：2  下载次数：0

分享到：

浏览次数：2

下载次数：0

打印次数：0