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Gold nanoparticles for high-throughput genotyping of long-range haplotypes 期刊论文

编号：

969b1876-3d26-4067-b155-e4d052685cf1
作者：

Chen, Peng^[1] Pan, Dun^[2] Fan, Chunhai^[1,2] Chen, Jianhua^[1] Huang, Ke^[1] Wang, Dongfang^[2] Zhang, Honglu^[2] Li, You^[1] Feng, Guoyin^[1] Liang, Peiji^[3] He, Lin^[1,4,5] Shi, Yongyong^[1,6]
语种：

English
期刊：

NATURE NANOTECHNOLOGY ISSN：1748-3387 2011 年 6 卷 10 期 (639 - 644) ; OCT
收录：
摘要：

Completion of the Human Genome Project(1) and the HapMap Project(2) has led to increasing demands for mapping complex traits in humans to understand the aetiology of diseases(3). Identifying variations in the DNA sequence, which affect how we develop disease and respond to pathogens and drugs, is important for this purpose, but it is difficult to identify these variations in large sample sets(3-5). Here we show that through a combination of capillary sequencing and polymerase chain reaction assisted by gold nanoparticles, it is possible to identify several DNA variations that are associated with age-related macular degeneration(6-8) and psoriasis(9) on significant regions of human genomic DNA. Our method is accurate and promising for large-scale and high-throughput genetic analysis of susceptibility towards disease and drug resistance(10-12).
推荐引用方式
GB/T 7714：

Chen Peng,Pan Dun,Fan Chunhai, et al. Gold nanoparticles for high-throughput genotyping of long-range haplotypes [J].NATURE NANOTECHNOLOGY,2011,6(10):639-644.
APA：

Chen Peng,Pan Dun,Fan Chunhai,Chen Jianhua,&Shi Yongyong.(2011).Gold nanoparticles for high-throughput genotyping of long-range haplotypes .NATURE NANOTECHNOLOGY,6(10):639-644.
MLA：

Chen Peng, et al. "Gold nanoparticles for high-throughput genotyping of long-range haplotypes" .NATURE NANOTECHNOLOGY 6,10(2011):639-644.

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