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Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse 期刊论文

编号：

96a97d0e-2b24-4106-84d0-0175e213a8b2
作者：

Chan, Anthony W. H.^[1];Yu, Shuangni^[2];Yu, YauHei^[1];Tong, Joanna H. M.^[1,3,4];Wang, Lei(王磊)^[5,6]Tin, Edith K. Y.^[1];Chong, Charing C. N.^[7];Chan, Stephen L.^[3,8];Wong, Grace L. H.^[3,9];Wong, Vincent W. S.^[3,9];Chan, Henry L. Y.^[3,9];Lai, Paul B. S.^[3,7];To, KaFai^[1,3,4];
语种：

English
期刊：

HISTOPATHOLOGY ISSN：0309-0167 2016 年 69 卷 6 期 (971 - 984) ; DEC
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关键词：

fatty liver hepatocellular carcinoma relapse steatohepatitis steatosis
摘要：

AimsSteatosis in hepatocellular carcinoma (HCC) has been recognized for decades and found most commonly in small, well-differentiated HCC. However, the clinicopathological features and pathogenesis of HCC with steatosis is not well characterized. There are few data concerning whether HCC with steatosis should be regarded a distinct histological variant, steatotic HCC. Methods and resultsA retrospective cohort of 516 patients undergoing curative surgery for primary HCC was recruited. The median follow-up was 45.5 (range: 0.2-166.0) months. Steatotic HCC was defined as HCC with significant steatosis (5% of tumour cells). Associations with immunohistochemical expression of fatty acid binding protein-1 (FABP1), sonic hedgehog (SHH) and gene polymorphism of patatin-like phospholipase 3 (PNPLA3) were analysed. Steatotic HCC was found in 21.1% of patients and was associated with higher metabolic risks [diabetes mellitus (36.7% versus 18.2%) and hypertension (44.0% versus 28.7%)], underlying fatty liver (60.6% versus 37.8%), steatohepatitis (30.3% versus 13.0%), smaller tumour size, lower frequency of major vessel (1.8% versus 11.3%) and microvascular invasion (20.2% versus 32.4%), earlier tumour stages and lower serum alpha-fetoprotein. It was associated with developing late tumour relapse (hazard ratio 2.15, P = 0.002) independently of underlying cirrhosis and non-anatomical excision. Steatotic HCC did not differ from HCC without significant steatosis in immunohistochemical expression of FABP1 and SHH and PNPLA3 gene polymorphism. ConclusionSteatotic HCC is a common histological variant of HCC with distinct association with underlying fatty liver, steatohepatitis and metabolic risks. Despite more favourable baseline tumour features, it was associated with late tumour relapse.
推荐引用方式
GB/T 7714：

Chan Anthony W. H.,Yu Shuangni,Yu Yau-Hei, et al. Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse [J].HISTOPATHOLOGY,2016,69(6):971-984.
APA：

Chan Anthony W. H.,Yu Shuangni,Yu Yau-Hei,Tong Joanna H. M.,&To Ka-Fai.(2016).Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse .HISTOPATHOLOGY,69(6):971-984.
MLA：

Chan Anthony W. H., et al. "Steatotic hepatocellular carcinoma: a variant associated with metabolic factors and late tumour relapse" .HISTOPATHOLOGY 69,6(2016):971-984.

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