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Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease 期刊论文

编号：

976ea599-9ab8-4ae7-8926-a92211b2bc77
作者：

Zhang, Chi(张弛)#^[1,2,3]Chen, Jie^[1,2,3];Feng, Chengcheng^[1,2,3];Shao, Xiayan(邵夏炎)^[1,2,3]Liu, Qingfeng(刘青锋)^[1,2,3]Zhang, Qizhi(张奇志)*^[1,2,3]Pang, Zhiqing^[1,2,3];Jiang, Xinguo(蒋新国)^[1,2,3]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF PHARMACEUTICS ISSN：0378-5173 2014 年 461 卷 1-2 期 (192 - 202) ; JAN 30
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关键词：

Basic fibroblast growth factor (bFGF) Solanum tuberosum lectin (STL) Brain delivery Nanoparticles Int ranasal administration Alzheimer's disease (AD)
摘要：

Disabilities caused by neurodegeneration have become one of the main causes of mortality in elderly population, with drug distribution to the brain remaining one of the most difficult challenges in the treatment of the central nervous system (CNS) diseases due to the existence of blood-brain barrier. Lectins modified polyethylene glycol-polylactide-polyglycolide (PEG-PLGA) nanoparticles could enhance the drug delivery to the brain following intranasal administration. In this study, basic fibroblast growth factor (bFGF) was entrapped in nanoparticles conjugated with Solanum tuberosum lectin (STL), which selectively binds to N-acetylglucosamine on the nasal epithelial membrane for its brain delivery. The resulting nanopartides had uniform particle size and negative zeta potential. The brain distribution of the formulations following intranasal administration was assessed using radioisotopic tracing method. The areas under the concentration-time curve of 125I-bFGF in the olfactory bulb, cerebrum, and cerebellum of rats following nasal application of STL modified nanoparticles (STL-bFGF-NP) were 1.79-5.17 folds of that of rats with intravenous administration, and 0.61-2.21 and 0.19-1.07 folds higher compared with intranasal solution and unmodified nanoparticles, respectively. Neuroprotective effect was evaluated using Mirror water maze task in rats with intracerebroventricular injection of p-amyloid25_35 and ibotenic acid. The spatial learning and memory of Alzheimer's disease (AD) rats in STL-bFGF-NP group were significantly improved compared with AD model group, and were also better than other preparations. The results were consistent with the value of choline acetyltransferase activity of rat hippocampus as well as the histological observations of rat hippocampal region. The histopathology assays also confirmed the in vivo safety of STL-bFGF-NP. These results clearly indicated that STL-NP was a promising drug delivery system for peptide and protein drugs such as bFGF to enter the CNS and play the therapeutic role. (C) 2014 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Chi,Chen Jie,Feng Chengcheng, et al. Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease [J].INTERNATIONAL JOURNAL OF PHARMACEUTICS,2014,461(1-2):192-202.
APA：

Zhang Chi,Chen Jie,Feng Chengcheng,Shao Xiayan,&Jiang Xinguo.(2014).Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease .INTERNATIONAL JOURNAL OF PHARMACEUTICS,461(1-2):192-202.
MLA：

Zhang Chi, et al. "Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease" .INTERNATIONAL JOURNAL OF PHARMACEUTICS 461,1-2(2014):192-202.

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