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Stability of Ethyl Glucuronide, Ethyl Sulfate, Phosphatidylethanols and Fatty Acid Ethyl Esters in Postmortem Human Blood 期刊论文

编号：

990e8bf7-b510-4098-971f-5489125be971
作者：

Liu, Yuming^[1];Zhang, Xinyu^[2,3];Li, Jiaolun^[2];Huang, Zhibin^[2];Lin, Zebin(林泽彬)^[2]Wang, Jingru^[4];Zhang, Chengqiang^[4];Rao, Yulan(饶渝兰)*^[2]
语种：

English
期刊：

JOURNAL OF ANALYTICAL TOXICOLOGY ISSN：0146-4760 2018 年 42 卷 5 期 (346 - 352) ; JUN
收录：
摘要：

The lack of systematic studies on the stability of ethanol's non-oxidative metabolites in postmortem specimens restricts their use in forensic cases. This study aimed to compare the stability of ethyl glucuronide (EtG), ethyl sulfate (EtS), phosphatidylethanols (PEths) and fatty acid ethyl esters (FAEEs) in postmortem human blood. Three groups were established based on the level and source of ethanol: the blank group, the ethanol-spiked group and the ethanol-positive group. Each group contained six blood samples from different corpses. The samples in each group were placed at 37, 25, 4 and -20 degrees C. Every 24 h for 7 days, 50 mu L was collected from each sample. The levels of EtG, EtS, PEths and FAEEs were determined by liquid chromatography-mass spectrometry, and their stability was evaluated. EtG was not detected in the blank group, but it was found in samples in the ethanol-spiked group placed at 37 degrees C, and it was degraded in the ethanol-positive group at 37 and 25 degrees C. EtS showed no change in any of the groups. PEths were not detected in the blank group, but formation was found in the ethanol-spiked group at all temperatures. In the ethanol-positive group, PEth levels fluctuated at 37 degrees C, decreased at 25 degrees C and increased at -20 degrees C. FAEEs were generated in the blank group and in the ethanol-spiked group at all temperatures. In the ethanol-positive group, FAEEs were degraded at 37 and 25 degrees C but were generated at 4 and -20 degrees C. EtS is a reliable biomarker of ethanol consumption, and EtG could be used as a biomarker at low temperatures (4 and -20 degrees C), but PEths and FAEEs are not appropriate biomarkers of ethanol consumption.
推荐引用方式
GB/T 7714：

Liu Yuming,Zhang Xinyu,Li Jiaolun, et al. Stability of Ethyl Glucuronide, Ethyl Sulfate, Phosphatidylethanols and Fatty Acid Ethyl Esters in Postmortem Human Blood [J].JOURNAL OF ANALYTICAL TOXICOLOGY,2018,42(5):346-352.
APA：

Liu Yuming,Zhang Xinyu,Li Jiaolun,Huang Zhibin,&Rao Yulan.(2018).Stability of Ethyl Glucuronide, Ethyl Sulfate, Phosphatidylethanols and Fatty Acid Ethyl Esters in Postmortem Human Blood .JOURNAL OF ANALYTICAL TOXICOLOGY,42(5):346-352.
MLA：

Liu Yuming, et al. "Stability of Ethyl Glucuronide, Ethyl Sulfate, Phosphatidylethanols and Fatty Acid Ethyl Esters in Postmortem Human Blood" .JOURNAL OF ANALYTICAL TOXICOLOGY 42,5(2018):346-352.

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