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Clinical and economic outcomes associated with community-acquired intra-abdominal infections caused by extended spectrum beta-lactamase (ESBL) producing bacteria in China 期刊论文

编号：

99655c9f-60de-47ab-833d-1ce6f1695687
作者：

Hu, Bijie^[2] Ye, Huifeng^[3] Xu, Yingchun^[4] Ni, Yuxing^[5] Hu, Yunjian^[6] Yu, Yunsong^[7] Huang, Zhenfei^[8] Ma, Larry^[1]
语种：

English
期刊：

CURRENT MEDICAL RESEARCH AND OPINION ISSN：0300-7995 2010 年 26 卷 6 期 (1443 - 1449) ; JUN
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关键词：

China Clinical outcome Community-acquired infection Economic outcome Extended spectrum beta-lactamase (ESBL)
摘要：

Background: To compare clinical and economic outcomes in patients with community-acquired intra-abdominal infection (IAI) due to extended spectrum beta-lactamase (ESBL) producing (ESBL-positive) bacteria versus non-ESBL-producing (ESBL-negative) bacteria in China. Methods: This was a retrospective chart review study of patients hospitalized with community-acquired IAI due to ESBL-positive or ESBL-negative infections caused by Escherichia coli or Klebsiella spp. Data were collected from six hospitals in China that participated in the Study for Monitoring Antibiotic Resistance Trends (SMART) during 2006-2007. Outcomes included clinical response at discharge and following first-line antibiotic, number of antibiotic agents and classes, duration of hospitalization, and overall hospitalization and intravenous antibiotic costs. Results: Of the 85 patients included in the study, 32 (37.6%) had ESBL-positive and 53 (62.4%) had ESBL-negative infections; E. coli was responsible for 77.6% of infections. Infection resolved at discharge in 30 (93.8%) ESBL-positive and 48 (90.6%) ESBL-negative patients (P=NS). Fewer ESBL-positive patients achieved complete response following first-line antibiotics (56.3% versus 83.0%; P=0.01). ESBL-positive patients required longer antibiotic treatment, more antibiotics, longer hospitalization (24.3 versus 14.6 days; 1.67-fold ratio; P=0.001), and incurred higher hospitalization costs (4,604 vs. 3,788; $ 3604 vs. $ 2020; 1.78-fold ratio; P<0.001). Conclusions: Patients with ESBL-positive infection had similar resolution rates at discharge compared to those with ESBL-negative infection, despite poorer first-line antibiotic response. However, ESBL-positive infection led to significantly greater hospitalization cost and intravenous antibiotic cost, and longer hospital stay.
推荐引用方式
GB/T 7714：

Hu Bijie,Ye Huifeng,Xu Yingchun, et al. Clinical and economic outcomes associated with community-acquired intra-abdominal infections caused by extended spectrum beta-lactamase (ESBL) producing bacteria in China [J].CURRENT MEDICAL RESEARCH AND OPINION,2010,26(6):1443-1449.
APA：

Hu Bijie,Ye Huifeng,Xu Yingchun,Ni Yuxing,&Ma Larry.(2010).Clinical and economic outcomes associated with community-acquired intra-abdominal infections caused by extended spectrum beta-lactamase (ESBL) producing bacteria in China .CURRENT MEDICAL RESEARCH AND OPINION,26(6):1443-1449.
MLA：

Hu Bijie, et al. "Clinical and economic outcomes associated with community-acquired intra-abdominal infections caused by extended spectrum beta-lactamase (ESBL) producing bacteria in China" .CURRENT MEDICAL RESEARCH AND OPINION 26,6(2010):1443-1449.

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