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Elevated expression of HIF-l alpha in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia 期刊论文

编号：

99eb6165-495d-41f3-bd89-ebbd512ec5dd
作者：

Wu, Fei^[1,2] Ding, Sentai^[1] Li, Xin^[1] Wang, Hui^[3] Liu, Shuai^[1] Wu, Haihu^[1] Bi, Dongbin^[1] Ding, Kejia^[1] Lu, Jiaju^[1]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 11 期 (12053 - 12062) ; MAR 15
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关键词：

benign prostatic hyperplasia(BPH) hypoxia inducible factor-1alpha(HIF-l alpha) acute urine retention(AUR) fetal prostate(FP) Pathology Section
摘要：

Background: Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-age or older men. Increasing evidence has shown that BPH is associated with hypoxia microenvironment. Methods: We retrospectively collected patient data and tissue samples from fetal prostates(FP), normal prostates(NP), intra-acinar of BPH, peri-acinar of BPH, prostate cancers and sarcomas of prostate. The expression of HIF-l alpha, as well as VEGF was visualized by immunohistochemistry and statistically analyzed with clinical parameters. Results: Expression of HIF-l alpha was observed in intra-acinar of BPH (69.5%), prostate cancer (85.7%) and all FPs, while NP and peri-acinar of BPH tissues were all stained negative. HIF-la levels in FPs and the malignant tumors were higher than BPH tissues(p < 0.05), and the expression of HIF-la in intra-acinar of BPH was higher than NP and peri-acinar of BPH (p < 0.05). The expression of HIF-la was correlated with the weight of intra-acinar of prostate (p < 0.05). And patients with prostate weight larger that 72.45g were prone to have HIF-la moderate-positive expression, according to the ROC curve (AUC = 0.734, 95% CI = 0.630-0.838). Moreover, the risk of acute urine retention (AUR) for HIF-la moderate-positive patients increased significantly (OR= 5.517, 95% CI = 2.434-12.504). Conclusions: HIF-la expression is increased in highly proliferative prostate tissues and correlated with the weight of intra-acinar prostate. Moreover, HIF-l alpha is also an independent risk factor for AUR occurrence in BPH patients.
推荐引用方式
GB/T 7714：

Wu Fei,Ding Sentai,Li Xin, et al. Elevated expression of HIF-l alpha in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia [J].ONCOTARGET,2016,7(11):12053-12062.
APA：

Wu Fei,Ding Sentai,Li Xin,Wang Hui,&Lu Jiaju.(2016).Elevated expression of HIF-l alpha in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia .ONCOTARGET,7(11):12053-12062.
MLA：

Wu Fei, et al. "Elevated expression of HIF-l alpha in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia" .ONCOTARGET 7,11(2016):12053-12062.

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