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Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent 期刊论文

编号：

9be1e105-8f42-4750-b5bc-bde82ebdb544
作者：

Zhan Ling^[1,2];Zhang Yanling^[1,2];Feng Zhe^[1,2];Chen Kui^[1,2];Zhou Xiushi^[1,2];Yu Min(于敏)^[1,2]Mo Wei(莫炜)^[1,2]
语种：

English
期刊：

EUROPEAN JOURNAL OF PHARMACOLOGY ISSN：0014-2999 2014 年 738 卷 (293 - 300) ; SEP 5
收录：
关键词：

Recombinant human tyrosyl tRNA synthetase Thrombocytopenia Cyclophosphamide Aggregation of megakaryocytes Vascular cell adhesion molecule
摘要：

chemo- and radiotherapy induced thrombocytopenia present significant limitations for tumor therapy. In this study, we examined the therapeutic effect of recombinant human tyrosyl-tRNA synthetase (rhTyrRS) against development of thrombocytopenia in cyclophosphamide (CTX) treated mice. Our data indicate that intraperitoneal administration of at least 10 mu g/day rhTyrRS for 7 days significantly prevents the decrease in platelets 8 days after CTX injection. The data further demonstrate that rhTyrRS promotes migration and aggregation of megakaryocytes to the bone marrow niche. Real-time PCR and flow cytometry reveal that VCAM-1 is particularly important for the adhesion. Together, these data suggest that rhTyrRS might be a useful therapeutic agent for chemotherapy-induced thrombocytopenia. (C) 2014 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Zhan Ling,Zhang Yanling,Feng Zhe, et al. Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent [J].EUROPEAN JOURNAL OF PHARMACOLOGY,2014,738:293-300.
APA：

Zhan Ling,Zhang Yanling,Feng Zhe,Chen Kui,&Mo Wei.(2014).Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent .EUROPEAN JOURNAL OF PHARMACOLOGY,738:293-300.
MLA：

Zhan Ling, et al. "Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent" .EUROPEAN JOURNAL OF PHARMACOLOGY 738(2014):293-300.

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