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Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy 期刊论文

编号：

9c79d5e8-8b1a-4908-9070-e3b236817d7e
作者：

Yuan, Hengfeng(袁恒峰)#^[1,2]Jiang, Wen^[3];von Roemeling, Christina A.^[2,4];Qie, Yaqing^[2];Liu, Xiujie^[2];Chen, Yuanxin^[2];Wang, Yifan^[5];Wharen, Robert E.^[2];Yun, Kyuson^[6];Bu, Guojun^[7];Knutson, Keith L.^[8,9];Kim, Betty Y. S.^[2,7,8];
语种：

English
期刊：

NATURE NANOTECHNOLOGY ISSN：1748-3387 2017 年 12 卷 8 期 (763 - +) ; AUG
收录：
摘要：

Tumour-targeted immunotherapy offers the unique advantage of specific tumouricidal effects with reduced immune-associated toxicity(1,2). However, existing platforms suffer from low potency, inability to generate long-term immune memory and decreased activities against tumour-cell subpopulations with low targeting receptor levels(3-5). Here we adopted a modular design approach that uses colloidal nanoparticles as substrates to create a multivalent bi-specific nanobioconjugate engager (mBiNE) to promote selective, immune-mediated eradication of cancer cells. By simultaneously targeting the human epidermal growth factor receptor 2 (HER2) expressed by cancer cells(6) and pro-phagocytosis signalling mediated by calreticulin(7), the mBiNE stimulated HER2-targeted phagocytosis and produced durable antitumour immune responses against HER2-expressing tumours. Interestingly, although the initial immune activation mediated by the mBiNE was receptor dependent, the subsequent antitumour immunity also generated protective effects against tumour-cell populations that lacked the HER2 receptor. Thus, the mBiNE represents a new targeted, nanomaterial-immunotherapy platform to stimulate innate and adaptive immunity and promote a universal antitumour response.
推荐引用方式
GB/T 7714：

Yuan Hengfeng,Jiang Wen,von Roemeling Christina A., et al. Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy [J].NATURE NANOTECHNOLOGY,2017,12(8):763-+.
APA：

Yuan Hengfeng,Jiang Wen,von Roemeling Christina A.,Qie Yaqing,&Kim Betty Y. S..(2017).Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy .NATURE NANOTECHNOLOGY,12(8):763-+.
MLA：

Yuan Hengfeng, et al. "Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy" .NATURE NANOTECHNOLOGY 12,8(2017):763-+.

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