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Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53-and caspase-3-mediated mechanisms 期刊论文

编号：

9cba302b-bc0d-4d41-8fb8-4a36ecec59ac
作者：

Shi, Min^[1] Lu, XiaoJie^[1,2] Zhang, Juan^[3,4] Diao, Hua^[5] Li, Guangming^[6] Xu, Ling^[1] Wang, Ting^[1] Wei, Jue^[1] Meng, Wenying^[1] Ma, JiaLi^[1] Yu, Heguo^[5] Wang, YuGang^[1]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 16 期 (22623 - 22631) ; APR 19
收录：
关键词：

oridonin lysine acetyltransferase inhibitor gastric cancer antiproliferation apoptosis
摘要：

Lysine acetylation has been reported to involve in the pathogenesis of multiple diseases including cancer. In our screening study to identify natural compounds with lysine acetyltransferase inhibitor (KATi) activity, oridonin was found to possess acetyltransferase-inhibitory effects on multiple acetyltransferases including P300, GCN5, Tip60, and pCAF. In gastric cancer cells, oridonin treatment inhibited cell proliferation in a concentration-dependent manner and down-regulated the expression of p53 downstream genes, whereas p53 inhibition by PFT-a reversed the antiproliferative effects of oridonin. Moreover, oridonin treatment induced cell apoptosis, increased the levels of activated caspase-3 and caspase-9, and decreased the mitochondrial membrane potential in gastric cancer cells in a concentration-dependent manner. Caspase-3 inhibition by Ac-DEVD-CHO reversed the proapoptosis effect of oridonin. In conclusion, our study identified oridonin as a novel KATi and demonstrated its tumor suppressive effects in gastric cancer cells at least partially through p53- and caspase-3-mediated mechanisms.
推荐引用方式
GB/T 7714：

Shi Min,Lu Xiao-Jie,Zhang Juan, et al. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53-and caspase-3-mediated mechanisms [J].ONCOTARGET,2016,7(16):22623-22631.
APA：

Shi Min,Lu Xiao-Jie,Zhang Juan,Diao Hua,&Wang Yu-Gang.(2016).Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53-and caspase-3-mediated mechanisms .ONCOTARGET,7(16):22623-22631.
MLA：

Shi Min, et al. "Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53-and caspase-3-mediated mechanisms" .ONCOTARGET 7,16(2016):22623-22631.

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