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MemHsp70 Receptor-mediated Multifunctional Ordered Mesoporous Carbon Nanospheres for Photoacoustic Imaging-Guided Synergistic Targeting Trimodal Therapy 期刊论文

编号：

9d0da00a-e3b5-4497-8886-54669f082d3e
作者：

Wang, Shanshan^[2];Li, Chengyi(李诚意)^[2]Meng, Ying^[2];Qian, Min^[2];Jiang, Huiling^[2];Du, Yilin^[2];Huang, Rongqin(黄容琴)^[2]Wang, Yi^[1,3];
语种：

English
期刊：

ACS BIOMATERIALS SCIENCE & ENGINEERING ISSN：2373-9878 2017 年 3 卷 8 期 (1702 - 1709) ; AUG
收录：
关键词：

TKD peptide multifunctional oxidized mesoporous carbon nanospheres photoacoustic imaging trimodal therapy breast cancer
摘要：

Integrating multiple discrete function-related theranostic modalities into one platform for effective cancer treatments has been considered to be a challenge for current nanomedicine design. In this work, a "four-in-one" theranostic system was simply prepared and developed for photoacoustic (PA) imaging-guided synergistic targeting chemo-gene-thermo trimodal therapy of breast cancer. In this system, polyethylene glycol (PEG)-bridged polyethylenimine (PEI) and a memHsp70 receptor-targeting peptide (TKD), PPT, was uniformly capped on doxorubicin (DOX)-loaded oxidized mesoporous carbon nanospheres (OMCN) to encapsulate therapeutic genes into cancer cells via active targeting accumulation. Taking both the advantages of OMCN (high photothermal conversion, strong PA contrast, and controllable drug loading) and the hydrophilic polymer (gene vector, switchable pores' cap, and targeting ability), the "four-in-one" theranostic system exhibited distinct PA imaging visualization, NIR/pH sensitive drug/gene release, and synergistic targeting therapeutic outcome, which were much superior than the single therapy or the combination of two treatments.
推荐引用方式
GB/T 7714：

Wang Shanshan,Li Chengyi,Meng Ying, et al. MemHsp70 Receptor-mediated Multifunctional Ordered Mesoporous Carbon Nanospheres for Photoacoustic Imaging-Guided Synergistic Targeting Trimodal Therapy [J].ACS BIOMATERIALS SCIENCE & ENGINEERING,2017,3(8):1702-1709.
APA：

Wang Shanshan,Li Chengyi,Meng Ying,Qian Min,&Wang Yi.(2017).MemHsp70 Receptor-mediated Multifunctional Ordered Mesoporous Carbon Nanospheres for Photoacoustic Imaging-Guided Synergistic Targeting Trimodal Therapy .ACS BIOMATERIALS SCIENCE & ENGINEERING,3(8):1702-1709.
MLA：

Wang Shanshan, et al. "MemHsp70 Receptor-mediated Multifunctional Ordered Mesoporous Carbon Nanospheres for Photoacoustic Imaging-Guided Synergistic Targeting Trimodal Therapy" .ACS BIOMATERIALS SCIENCE & ENGINEERING 3,8(2017):1702-1709.

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