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High level of BRD4 promotes non-small cell lung cancer progression 期刊论文

编号：

9d90ced7-fc0f-4f87-a2d9-d5b93e78ab2d
作者：

Liao, YunFei^[1,2];Wu, YongBing^[2];Long, Xiang^[2];Zhu, ShuQiang^[2];Jin, Chun^[1];Xu, JianJun^[2];Ding, JianYong(丁建勇)*^[1]
语种：

English
期刊：

ONCOTARGET ISSN：1949-2553 2016 年 7 卷 8 期 (9492 - 9501) ; FEB 23
收录：
关键词：

non-small cell lung cancer bromodomain containing protein 4 proliferation invasion apoptosis
摘要：

Bromodomain containing protein 4 (BRD4), a member of the bromodomain and extra terminal domain (BET) protein family, has been shown to play important roles in tumor progression. However, its role in non-small cell lung cancer (NSCLC) is still largely unknown. Here, we found that BRD4 expression was significantly upregulated in NSCLC tissues and NSCLC cell lines with higher invasion and metastasis potentials. Suppression of BRD4 expression in NSCLC cell lines impaired cell invasion, inhibited cell proliferation, and accelerated cell apoptosis. Clinically, we observed that the BRD4 level was significantly related to histological type, lymph node metastasis, tumor stage and differentiation. More importantly, high level of BRD4 was closely correlated with the poor prognosis of NSCLC patients. Therefore, our study suggests that BRD4 is one of the major contributors to the invasion-prone phenotype of NSCLC, and a potential therapeutic target of NSCLC.
推荐引用方式
GB/T 7714：

Liao Yun-Fei,Wu Yong-Bing,Long Xiang, et al. High level of BRD4 promotes non-small cell lung cancer progression [J].ONCOTARGET,2016,7(8):9492-9501.
APA：

Liao Yun-Fei,Wu Yong-Bing,Long Xiang,Zhu Shu-Qiang,&Ding Jian-Yong.(2016).High level of BRD4 promotes non-small cell lung cancer progression .ONCOTARGET,7(8):9492-9501.
MLA：

Liao Yun-Fei, et al. "High level of BRD4 promotes non-small cell lung cancer progression" .ONCOTARGET 7,8(2016):9492-9501.

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