Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss. Many regulatory factors, including signaling pathways, transcription factors, and epigenetic regulators, play roles in hair cell regeneration in various species. In this chapter, we review the history of hair cell regeneration research, the methods used in the study of hair cell regeneration, the properties and modulating factors of inner ear stem cells, and the re-formation of cochlear ribbon synapses and hearing function recovery.
[1]Fudan Univ, ENT Inst, Shanghai, Peoples R China;
[2]Fudan Univ, Affiliated Eye & ENT Hosp, Dept Otorhinolaryngol, Shanghai, Peoples R China;
[3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai Engn Res Ctr Cochlear Implant, Shanghai, Peoples R China;
[4]Southeast Univ, Key Lab Dev Genes & Human Dis, Jiangsu Prov High Tech Key Lab Biomed Res, Minist Educ,Inst Life Sci, Nanjing, Jiangsu, Peoples R China;
[5]Southeast Univ, Inst Life Sci, MOE Key Lab Dev Genes & Human Dis, Jiangsu Prov High Tech Key Lab Biomed Res, Nanjing, Peoples R China;
[6]Fudan Univ, Key Lab Hearing Med NHFPC, ENT Inst, Shanghai, Peoples R China;
[7]Fudan Univ, State Key Lab Med Neurobiol, Shanghai Engn Res Ctr Cochlear Implant, Otorhinolaryngol Dept,Affiliated Eye & ENT Hosp, Shanghai, Peoples R China
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