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Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome 期刊论文

编号：

9e0bd2c8-5a61-4c5d-a8d1-47be1f3dd845
作者：

Xu, Cheng^[1];Wang, Zhengyuan^[1];Cui, Rongrong^[1];He, Hongyu(贺黉裕)^[2]Lin, Xiaoyan^[1];Sheng, Yuan^[3];Zhang, Hongwei(张宏伟)^[4]
语种：

English
期刊：

BMC CANCER ISSN：1471-2407 2015 年 15 卷 ; NOV 23
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关键词：

Breast cancer TGF-beta PTHrP Prognosis Survival analysis
摘要：

Background: Better methods to predict prognosis can play a supplementary role in administering individualized treatment for breast cancer patients. Altered expressions of PTHrP and TGF-beta have been observed in various types of human cancers. The objective of the current study was to evaluate the association of PTHrP and TGF-beta level with the clinicopathological features of the breast cancer patients. Methods: Immunohistochemistry was used to examine PTHrP and TGF-beta protein expression in 497 cases of early breast cancer, and Kaplan-Meier method and COX's Proportional Hazard Model were applied to the prognostic value of PTHrP and TGF-beta expression. Results: Both over-expressed TGF-beta and PTHrP were correlated with the tumor in larger size, higher proportion of axillary lymph node metastasis and later clinical stage. Additionally, the tumors with a high TGF-beta level developed poor differentiation, and only TGF-beta expression was associated with disease-free survival (DFS) of the breast cancer patients. Followed up for a median of 48 months, it was found that only the patients with negative TGF-beta expression had longer DFS (P < 0.05, log-rank test). Nevertheless, those with higher PTHrP expression tended to show a higher rate of bone metastasis (67.6 % vs. 45.8 %, P = 0.019). In ER negative subgroup, those who developed PTHrP positive expression presented poor prognosis (P < 0.05, log-rank test). The patients with both positive TGF-beta and PTHrP expression were significantly associated with the high risk of metastases. As indicated by Cox's regression analysis, TGF-beta expression and the high proportion of axillary lymph node metastasis served as significant independent predictors for breast cancer recurrence. Conclusions: TGF-beta and PTHrP were confirmed to be involved in regulating the malignant progression in breast cancer, and PTHrP expression, to be associated with bone metastasis as a potential prognostic marker in ER negative breast cancer.
推荐引用方式
GB/T 7714：

Xu Cheng,Wang Zhengyuan,Cui Rongrong, et al. Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome [J].BMC CANCER,2015,15.
APA：

Xu Cheng,Wang Zhengyuan,Cui Rongrong,He Hongyu,&Zhang Hongwei.(2015).Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome .BMC CANCER,15.
MLA：

Xu Cheng, et al. "Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome" .BMC CANCER 15(2015).

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