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Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells 期刊论文

编号：

9ead9e3f-4d8c-4296-a412-b5acacdc9cc5
作者：

Ding, Keshuo^[1,2] Banerjee, Arindam^[5,6] Tan, Sheng^[1,2] Zhao, JunSong^[1,2] Zhuang, Qian^[1,2] Li, Rui^[1,2] Qian, Pengxu^[1,2] Liu, Suling^[1,2] Wu, ZhengSheng^[1,2,3,4] Lobie, Peter E.^[5,6,7] Zhu, Tao^[1,2]
语种：

English
期刊：

JOURNAL OF BIOLOGICAL CHEMISTRY ISSN：0021-9258 2014 年 289 卷 23 期 (16057 - 16071) ; JUN 6
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摘要：

Previous studies have demonstrated that Artemin (ARTN) functions as a cancer stem cell (CSC) and metastatic factor in mammary carcinoma. Herein, we report that ARTN mediates acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells. Ligands that increase HER2 activity increased ARTN expression in HER2-positive mammary carcinoma cells, whereas trastuzumab inhibited ARTN expression. Forced expression of ARTN decreased the sensitivity of HER2-positive mammary carcinoma cells to trastuzumab both in vitro and in vivo. Conversely, siRNA-mediated depletion of ARTN enhanced trastuzumab efficacy. Cells with acquired resistance to trastuzumab exhibited increased ARTN expression, the depletion of which restored trastuzumab sensitivity. Trastuzumab resistance produced an increased CSC population concomitant with enhanced mammospheric growth. ARTN mediated the enhancement of the CSC population by increased BCL-2 expression, and the CSC population in trastuzumab-resistant cells was abrogated upon inhibition of BCL-2. Hence, we conclude that ARTN is one mediator of acquired resistance to trastuzumab in HER2-positive mammary carcinoma cells.
推荐引用方式
GB/T 7714：

Ding Keshuo,Banerjee Arindam,Tan Sheng, et al. Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells [J].JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(23):16057-16071.
APA：

Ding Keshuo,Banerjee Arindam,Tan Sheng,Zhao JunSong,&Zhu Tao.(2014).Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells .JOURNAL OF BIOLOGICAL CHEMISTRY,289(23):16057-16071.
MLA：

Ding Keshuo, et al. "Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells" .JOURNAL OF BIOLOGICAL CHEMISTRY 289,23(2014):16057-16071.

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