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Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy 期刊论文

编号：

9fba9a40-11b4-4f41-809e-f54ad507ab70
作者：

Qian, Xin^[1];Li, Xinghui^[2,3];Ma, Fenfen^[1];Luo, Shanshan(罗姗姗)^[1]Ge, Ruowen^[4];Zhu, Yizhun(朱依谆)^[1,5]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2016 年 473 卷 4 期 (931 - 938) ; MAY 13
收录：
关键词：

S-propargyl-cysteine Diabetic nephropathy Albuminuria Extracellular matrix Mesangial cell Fibrosis
摘要：

In this work, we demonstrated for the first time that S-propargyl-cysteine (SPRC, also named as ZYZ-802), a novel hydrogen sulfide (H2S)-releasing compound, had renoprotective effects on streptozotocin (STZ)-induced diabetic kidney injury. SPRC treatment significantly reduced the level of creatinine, kidney to body weight ratio and in particular, markedly decreased 24-h urine microalbuminuria excretion. SPRC suppressed the mRNA expression of fibronectin and type IV collagen. In vitro, SPRC inhibited mesangial cells over-proliferation and hypertrophy induced by high glucose. Additionally, SPRC attenuated inflammation in diabetic kidneys. SPRC also reduced transforming growth factor beta 1 (TGF-beta 1) signaling and expression of phosphorylated Smad3 (p-Smad3) pathway. Moreover, SPRC inhibited phosphorylation of ERK, p38 protein. Taken together, SPRC was demonstrated to be a potential therapeutic candidate to suppress diabetic nephropathy. (C) 2016 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Qian Xin,Li Xinghui,Ma Fenfen, et al. Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,473(4):931-938.
APA：

Qian Xin,Li Xinghui,Ma Fenfen,Luo Shanshan,&Zhu Yizhun.(2016).Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,473(4):931-938.
MLA：

Qian Xin, et al. "Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 473,4(2016):931-938.

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