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Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila 期刊论文

编号：

a024f9fb-d6b2-4544-a71f-e253ee5c8beb
作者：

Wang, Xiaoke^[1,2] Chen, Minjie^[2,3] Zhong, Mianhua^[4] Hu, Ziying^[2] Qiu, Lianglin^[2,5,6] Rajagopalan, Sanjay^[2] Fossett, Nancy G.^[5,6] Chen, Lungchi^[7] Ying, Zhekang^[1,2,3]
语种：

English
期刊：

TOXICOLOGICAL SCIENCES ISSN：1096-6080 2017 年 156 卷 1 期 (199 - 207) ; MAR
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关键词：

drosophila PM2.5 lifespan inflammation-associated signaling oxidative stress
摘要：

Exposure to ambient PM2.5 is associated with human premature mortality. However, it has not yet been toxicologically replicated, likely due to the lack of suitable animal models. Drosophila is frequently used in longevity research due to many incomparable merits. The present study aims to validate Drosophila models for PM2.5 toxicity study through characterizing their biological responses to exposure to concentrated ambient PM2.5 (CAP). The survivorship curve demonstrated that exposure to CAP markedly reduced lifespan of Drosophila. This antilongevity effect of CAP exposure was observed in both male and female Drosophila, and by comparison, the male was more sensitive [50% survivals: 20 and 48 days, CAP-and filtered air (FA)-exposed males, respectively; 21 and 40 days, CAP-and FA-exposed females, respectively]. Similar to its putative pathogenesis in humans, CAP exposure-induced premature mortality in Drosophila was also coincided with activation of pro-inflammatory signaling pathways including Jak, Jnk, and Nf-jb and increased systemic oxidative stress. Furthermore, like in humans and mammals, exposure to CAP significantly increased whole-body and circulating glucose levels and increased mRNA expression of Ilp2 and Ilp5, indicating that CAP exposure induces dysregulated insulin signaling in Drosophila. Similar to effects on humans, exposure to CAP leads to premature mortality likely through induction of inflammation-associated signaling, oxidative stress, and metabolic abnormality in Drosophila, strongly supporting that it can be a useful model organism for PM2.5 toxicity study.
推荐引用方式
GB/T 7714：

Wang Xiaoke,Chen Minjie,Zhong Mianhua, et al. Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila [J].TOXICOLOGICAL SCIENCES,2017,156(1):199-207.
APA：

Wang Xiaoke,Chen Minjie,Zhong Mianhua,Hu Ziying,&Ying Zhekang.(2017).Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila .TOXICOLOGICAL SCIENCES,156(1):199-207.
MLA：

Wang Xiaoke, et al. "Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila" .TOXICOLOGICAL SCIENCES 156,1(2017):199-207.

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