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Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses 期刊论文

编号：

a0266650-6d6d-4fe6-9725-35e7f18a8b28
作者：

Holm, Christian K.^[1,2] Rahbek, Stine H.^[1,2] Gad, Hans Henrik^[2,3] Bak, Rasmus O.^[1,2] Jakobsen, Martin R.^[1,2] Jiang, Zhaozaho^[4] Hansen, Anne Louise^[1,2] Jensen, Simon K.^[1] Sun, Chenglong^[1,2] Thomsen, Martin K.^[1,2] Laustsen, Anders^[1,2] Nielsen, Camilla G.^[1,2] Severinsen, Kasper^[5] Xiong, Yingluo^[1,6] Burdette, Dara L.^[7] Hornung, Veit^[8] Lebbink, Robert Jan^[9] Duch, Mogens^[3,10] Fitzgerald, Katherine A.^[4] Bahrami, Shervin^[3,10] Mikkelsen, Jakob Giehm^[1,2] Hartmann, Rune^[2,3] Paludan, Soren R.^[1,2]
语种：

English
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2016 年 7 卷 ; FEB
收录：
摘要：

Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV.
推荐引用方式
GB/T 7714：

Holm Christian K.,Rahbek Stine H.,Gad Hans Henrik, et al. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses [J].NATURE COMMUNICATIONS,2016,7.
APA：

Holm Christian K.,Rahbek Stine H.,Gad Hans Henrik,Bak Rasmus O.,&Paludan Soren R..(2016).Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses .NATURE COMMUNICATIONS,7.
MLA：

Holm Christian K., et al. "Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses" .NATURE COMMUNICATIONS 7(2016).

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