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Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins 期刊论文

编号：

a0e435dc-d0c7-483b-8197-40e09d0faad7
作者：

Xu, Jun^[1] Lee, Steve SeungYoung^[2,3] Seo, Howon^[4,5] Pang, Liang^[6] Jun, Yearin^[7,8] Zhang, RuoYu^[9] Zhang, ZhongYin^[9] Kim, Pilhan^[4,5,10] Lee, Wooin^[7,8] Kron, Stephen J.^[2,3] Yeo, Yoon^[1,11]
语种：

English
期刊：

SMALL ISSN：1613-6810 2018 年 14 卷 50 期 ; DEC 13
收录：
关键词：

drug delivery polymeric nanoparticles quinic acid selectin tumor microenvironment
摘要：

Current nanoparticle (NP) drug carriers mostly depend on the enhanced permeability and retention (EPR) effect for selective drug delivery to solid tumors. However, in the absence of a persistent EPR effect, the peritumoral endothelium can function as an access barrier to tumors and negatively affect the effectiveness of NPs. In recognition of the peritumoral endothelium as a potential barrier in drug delivery to tumors, poly(lactic-co-glycolic acid) (PLGA) NPs are modified with a quinic acid (QA) derivative, synthetic mimic of selectin ligands. QA-decorated NPs (QA-NP) interact with human umbilical vein endothelial cells expressing E-/P-selectins and induce transient increase in endothelial permeability to translocate across the layer. QA-NP reach selectin-upregulated tumors, achieving greater tumor accumulation and paclitaxel (PTX) delivery than polyethylene glycol-decorated NPs (PEG-NP). PTX-loaded QA-NP show greater anticancer efficacy than Taxol or PTX-loaded PEG-NP at the equivalent PTX dose in different animal models and dosing regimens. Repeated dosing of PTX-loaded QA-NP for two weeks results in complete tumor remission in 40-60% of MDA-MB-231 tumor-bearing mice, while those receiving control treatments succumb to death. QA-NP can exploit the interaction with selectin-expressing peritumoral endothelium and deliver anticancer drugs to tumors to a greater extent than the level currently possible with the EPR effect.
推荐引用方式
GB/T 7714：

Xu Jun,Lee Steve Seung-Young,Seo Howon, et al. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins [J].SMALL,2018,14(50).
APA：

Xu Jun,Lee Steve Seung-Young,Seo Howon,Pang Liang,&Yeo Yoon.(2018).Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins .SMALL,14(50).
MLA：

Xu Jun, et al. "Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins" .SMALL 14,50(2018).

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