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Combined Effects of Flow Diverting Strategies and Parent Artery Curvature on Aneurysmal Hemodynamics: A CFD Study 期刊论文

编号：

a119b2fa-4273-4b04-b973-75058fedd26a
作者：

Xu, Jinyu^[1] Wu, Zhichen^[2] Yu, Ying^[1] Lv, Nan^[1] Wang, Shengzhang^[3] Karmonik, Christof^[4] Liu, JianMin^[1] Huang, Qinghai^[1]
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 9 期 ; SEP 23
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摘要：

Purpose Flow diverters (FD) are increasingly being considered for treating large or giant wide-neck aneurysms. Clinical outcome is highly variable and depends on the type of aneurysm, the flow diverting device and treatment strategies. The objective of this study was to analyze the effect of different flow diverting strategies together with parent artery curvature variations on altering intra-aneurysmal hemodynamics. Methods Four ideal intracranial aneurysm models with different parent artery curvature were constructed. Computational fluid dynamics (CFD) simulations of the hemodynamics before and after applying five types of flow diverting strategies (single FD, single FD with 5% and 10% packing density of coils, two FDs with 25% and 50% overlapping rate) were performed. Changes in pressure, wall shear stress (WSS), relative residence time (RRT), inflow velocity and inflow volume rate were calculated and compared. Results Each flow diverting strategy resulted in enhancement of RRT and reduction of normalized mean WSS, inflow volume rate and inflow velocity in various levels. Among them, 50% overlapped FD induced most effective hemodynamic changes in RRT and inflow volume rate. The mean pressure only slightly decreased after treatment. Regardless of the kind of implantation of FD, the mean pressure, inflow volume rate and inflow velocity increased and the RRT decreased as the curvature of the parent artery increased. Conclusions Of all flow diverting strategies, overlapping FDs induced most favorable hemodynamic changes. Hemodynamics alterations post treatment were substantially influenced by parent artery curvature. Our results indicate the need of an individualized flow diverting strategy that is tailored for a specific aneurysm.
推荐引用方式
GB/T 7714：

Xu Jinyu,Wu Zhichen,Yu Ying, et al. Combined Effects of Flow Diverting Strategies and Parent Artery Curvature on Aneurysmal Hemodynamics: A CFD Study [J].PLOS ONE,2015,10(9).
APA：

Xu Jinyu,Wu Zhichen,Yu Ying,Lv Nan,&Huang Qinghai.(2015).Combined Effects of Flow Diverting Strategies and Parent Artery Curvature on Aneurysmal Hemodynamics: A CFD Study .PLOS ONE,10(9).
MLA：

Xu Jinyu, et al. "Combined Effects of Flow Diverting Strategies and Parent Artery Curvature on Aneurysmal Hemodynamics: A CFD Study" .PLOS ONE 10,9(2015).

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