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Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum 期刊论文

编号：

a1c0e1c4-72f9-47d6-8027-493a97013200
作者：

Guo, Liang^[2,3];Xie, Jianhui(谢建辉)^[2,3]Ruan, Yuanyuan^[2,3];Zhou, Lei^[2,3];Zhu, Haiyan^[2,3];Yun, Xiaojing^[2,3];Jiang, Yan^[4];Lue, Long^[4];Chen, Kangli^[2,3];Min, Zhihui^[5];Wen, Yumei(闻玉梅)*^[1]Gu, Jianxin(顾建新)^[2,3]
语种：

English
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2009 年 9 卷 10 期 (1175 - 1182) ; SEP
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关键词：

Anti-tumor Glucan Dectin-1 Ganoderma lucidum Spores
摘要：

Spores of Ganoderma lucidum contain a large amount of bioactive substances and have a higher bioactivity than the fruit bodies of G. lucidum. However, ingredients from spores are less studied due to the difficulties in collecting the spores and breaking the rigid shell. In this study, a water-soluble polysaccharide named GSG was extracted from the spores of G. lucidum. GSG is characterized to be a branched glucan that contains several different kinds of linkages. It was an effective inducer of MAPKs- and Syk-dependent TNF-alpha and IL-6 secretion in murine resident peritoneal macrophages. Dectin-1 could recognize GSG and partially mediate its biological activities. Additionally, in vivo administration of GSG potentiated the Con A-induced proliferative response of splenocytes and induced anti-tumor activity against Lewis lung cancer in mice. Therefore, these results suggest that GSG is an effective immunomodulator and may be a promising adjuvant remedy for antitumor therapies. (C) 2009 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Guo Liang,Xie Jianhui,Ruan Yuanyuan, et al. Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2009,9(10):1175-1182.
APA：

Guo Liang,Xie Jianhui,Ruan Yuanyuan,Zhou Lei,&Gu Jianxin.(2009).Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum .INTERNATIONAL IMMUNOPHARMACOLOGY,9(10):1175-1182.
MLA：

Guo Liang, et al. "Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum" .INTERNATIONAL IMMUNOPHARMACOLOGY 9,10(2009):1175-1182.

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