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Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis 期刊论文

编号：

a3df8b88-857d-4ce3-aa1e-58338fe09468
作者：

Xu, Rong^[1];Han, QingFeng^[2];Zhu, TongYing(朱彤莹)^[3]Ren, Yeping^[4];Chen, JiangHua^[5];Zhao, HuiPing^[6];Chen, MengHua^[7];Dong, Jie^[1];Wang, Yue^[2];Hao, ChuanMing(郝传明)^[3]Zhang, Rui^[4];Zhang, Xiaohui^[5];Wang, Mei^[6];Tian, Na^[7];Wang, HaiYan^[1];
语种：

English
期刊：

PLOS ONE ISSN：1932-6203 2013 年 8 卷 11 期 ; NOV 18
收录：
摘要：

Background: Diabetic patients on peritoneal dialysis (PD) have lower survival and are more likely complicated with inflammation than their non-diabetic counterparts. Here, we explored the interaction effects between diabetes and inflammation on the survival of PD patients. Methods: Overall, 2,264 incident patients were enrolled from a retrospective cohort study in China. Patients were grouped according to the baseline levels of high-sensitive C-reactive protein (hsCRP, <= 3 mg/L or >3 mg/L) or serum albumin (SA, >= 38 g/L or <38 g/L). Then, several multivariable adjusted stratified Cox regsion models were constructed for these groups to explore the predicted role of diabetes on all-cause or cardiovascular death under inflammatory or non-inflammatory conditions. Results: Diabetics on PD were more likely to have inflammation than non-diabetics on PD, and they presented with elevated hsCRP (52.7% vs. 47.3%, P = 0.03) or decreased SA (77.9% vs. 62.7%, P < 0.001) levels. After stratification by size of center and controlling for confounding factors, diabetes was found to predict all-cause death in patients with hsCRP >3 mg/L or SA <38 g/L but not in patients with hsCRP <= 3 mg/L or SA >= 38 g/L. Similarly, the presence of diabetes was an indication of cardiovascular death in patients with hsCRP >3 mg/L or SA <38 g/L. However, if further adjusted by baseline cardiovascular disease, the predicted role of diabetes on death related to cardiovascular disease in patients with SA <38 g/L disappeared. Conclusion: Diabetic patients could do as well as non-diabetic patients without inflammation on peritoneal dialysis. Active strategies should be implemented to improve inflammation status in diabetic patients on PD.
推荐引用方式
GB/T 7714：

Xu Rong,Han QingFeng,Zhu TongYing, et al. Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis [J].PLOS ONE,2013,8(11).
APA：

Xu Rong,Han QingFeng,Zhu TongYing,Ren Yeping,&Wang HaiYan.(2013).Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis .PLOS ONE,8(11).
MLA：

Xu Rong, et al. "Diabetic Patients Could Do As Well as Non-Diabetic Patients without Inflammation on Peritoneal Dialysis" .PLOS ONE 8,11(2013).

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