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Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors 期刊论文

编号：

a41d7d4f-46fb-4421-9b1f-6dfd68edccd2
作者：

Zhu, Xiaoli[0]^[1] Zhang, Hongming[1]^[2] Lin, Yong[2]^[3] Chen, Pingsheng[3]^[4] Min, J. E.[4]^[5] Wang, Zhenzhong[5]^[6] Xiao, Wei[6]^[7] Chen, Baoan[7]^[8]
地址：

[1]Fudan University Shanghai Cancer Center, Department of Pathology,Shanghai,China
[2]Southeast University, Department of Hematology and Oncology,Nanjing,China
[3]Southeast University, Department of Pulmonary Medicine,Nanjing,China
[4]Southeast University, Department of Pathology and Pathophysiology,Nanjing,China
[5]Southeast University, Respiratory Diseases Department,Nanjing,China
[6]Kanion Pharmaceutical Co., Ltd.,,China
[7]Jiangsu Kanion Pharmaceutical Co. Ltd, State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process,,China
[8]Southeast University, Department of Hematology and Oncology (Key Department of Jiangsu Medicine),Nanjing,China
语种：

英文
期刊：

Journal of Chemotherapy ISSN：1120-009X 2009 年 21 卷 6 期 (666 - 672)
收录：
关键词：

Apoptosis Caspase 10 Gambogic acid p53 SK-MES-1
摘要：

Gambogic acid (GA) is one of the important active ingredients of gamboge. Our study examined the expression of transferrin receptors (TFR) on the cell surface of human lung SPC-A1 and SK-MES-1 cells and measured their GA-induced apoptosis rate. The results showed that SPC-A1 cells with a higher TFR expression were more sensitive at the same GA concentrations. To examine its distribution in cultured cells and study the mechanisms of apoptosis, we labeled GA with a ^12SI tracer and examined the expression of apoptosis-related proteins. We found that GA uptake into SPC-A1 cells was higher than into SK-MES-1 cells; apoptosis-related proteins Caspase 2, Caspase 9, Caspase 10, Bax and p53 were involved in GA-induced apoptosis. We conclude that GA has an apoptosis-promoting effect on non small cell lung cancer cells. In clinical practice, the histopathological quantitation of TFR expression levels in tumor tissues may become a predictor of the sensitivity of patients' tumors to GA treatment. ? E.S.I.F.T. srl.
推荐引用方式
GB/T 7714：

Zhu Xiaoli/55696701800[0],Zhang Hongming/35729799200[1],Lin Yong/35728788100[2], et al. Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors [J].Journal of Chemotherapy,2009,21(6):666-672.
APA：

Zhu Xiaoli/55696701800[0],Zhang Hongming/35729799200[1],Lin Yong/35728788100[2],Chen Pingsheng/7408355859[3],&Chen Baoan/7408611401[7].(2009).Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors .Journal of Chemotherapy,21(6):666-672.
MLA：

Zhu Xiaoli/55696701800[0], et al. "Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors" .Journal of Chemotherapy 21,6(2009):666-672.

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